TRAPPC3L
Trafficking Protein Particle Complex Subunit 3 Like
Gene Information Card
| Symbol | TRAPPC3L |
|---|---|
| Full Name | Trafficking Protein Particle Complex Subunit 3 Like |
| Gene Type | protein-coding |
| Chromosomal Location | 6q22.31 |
| NCBI Gene ID | 100131755 ncbi.nlm.nih.gov/gene/100131755 |
| Ensembl ID | ENSG00000204310 |
| UniProt ID | A6NIR3 |
| OMIM ID | 618842 |
| HGNC ID | 37244 |
| Aliases | C6orf211, dJ1033B10.3 |
Description
TRAPPC3L encodes a subunit-like protein of the trafficking protein particle (TRAPP) complex, which is involved in vesicle tethering and transport between the endoplasmic reticulum and Golgi apparatus. The protein shares homology with TRAPPC3 and may modulate TRAPP complex assembly or function.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not applicable | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 5.2 | Low |
| Lung | 3.1 | Low |
| Liver | 1.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 8.4 | Moderate expression |
| HeLa | 6.1 | Low expression |
| K562 | 2.3 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated mutations | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • ER to Golgi vesicle-mediated transport (GO:0006888) | • Golgi transport complex (GO:0017119) |
| • protein binding (GO:0005515) |
Pathways
• TRAPP complex mediated vesicle tethering
Protein Summary
TRAPPC3L is a 167-amino acid protein with a single transmembrane domain. It localizes to the Golgi apparatus and is thought to participate in vesicle tethering. Its exact role in TRAPP complex function remains under investigation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRAPPC3L Knockout HEK293 Cell Line | EDJ-KQ15904 | Human | 100128327 | Details Get a Quote |
| TRAPPC3L Knockout HeLa Cell Line | EDJ-KQ60788 | Human | 100128327 | Details Get a Quote |
| TRAPPC3L Knockout A-549 Cell Line | EDJ-KQ69256 | Human | 100128327 | Details Get a Quote |
| TRAPPC3L Knockout HCT 116 Cell Line | EDJ-KQ77614 | Human | 100128327 | Details Get a Quote |
