TRAP1 Gene (TNF Receptor-Associated Protein 1)
Mitochondrial Chaperone in Cancer and Neuroprotection
Gene Information Card
| Symbol | TRAP1 |
|---|---|
| Full Name | TNF receptor-associated protein 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 16p13.3 |
| NCBI Gene ID | 10131 ncbi.nlm.nih.gov/gene/10131 |
| Ensembl ID | ENSG00000126602 |
| UniProt ID | Q12931 |
| OMIM ID | 606219 |
| HGNC ID | 12006 |
| Aliases | HSP90L, HSP75, HSP90N, TRAP-1 |
Description
TRAP1 encodes a mitochondrial chaperone protein belonging to the HSP90 family. It is involved in protein folding, mitochondrial import, and protection against oxidative stress and apoptosis. TRAP1 is overexpressed in various cancers and is implicated in tumor cell survival and resistance to therapy.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Overexpression promotes cell proliferation and resistance to apoptosis via inhibition of cytochrome c release | PMID: 20010870 |
| Breast cancer | Upregulation correlates with poor prognosis; TRAP1 silencing reduces tumor growth | PMID: 24803677 |
| Parkinson's disease | Loss of TRAP1 function leads to mitochondrial dysfunction and increased oxidative stress | PMID: 24752235 |
| Huntington's disease | TRAP1 downregulation contributes to mitochondrial impairment in striatal cells | PMID: 21917919 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 12.5 | Medium |
| Liver | 8.3 | Low |
| Brain | 6.7 | Low |
| Colon | 15.2 | Medium |
| Breast | 14.8 | Medium |
| Prostate | 18.1 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 16.5 | Cervical cancer cell line |
| MCF7 | 14.2 | Breast cancer cell line |
| HCT116 | 19.8 | Colorectal cancer cell line |
| SH-SY5Y | 11.3 | Neuroblastoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1124A>G (p.Asn375Ser) | Missense | 0.01% (COSMIC) | Unknown functional effect |
| c.1487C>T (p.Thr496Met) | Missense | 0.02% (COSMIC) | Reported in colorectal cancer |
| c.1976G>A (p.Arg659Gln) | Missense | 0.005% (ClinVar) | Likely benign |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants may impair chaperone activity, leading to mitochondrial dysfunction.
Gain of Function (GOF)
Not well characterized; overexpression in tumors suggests potential gain-of-function in cell survival.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • protein folding (GO:0006457) | • unfolded protein binding (GO:0051082) |
| • mitochondrion (GO:0005739) | • negative regulation of apoptotic process (GO:0043066) |
| • apoptotic process (GO:0006915) | • cellular response to heat (GO:0034605) |
Pathways
• Apoptosis - modulation of cytochrome c release
• Mitochondrial protein import
• HSP90 chaperone cycle
• Oxidative stress response
Protein Summary
TRAP1 is a 75 kDa mitochondrial chaperone (UniProt Q12931) that belongs to the HSP90 family. It localizes to the mitochondrial matrix and assists in protein folding, mitochondrial import, and protection against stress-induced apoptosis. TRAP1 is overexpressed in multiple cancers and is considered a potential therapeutic target.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRAP1 Knockout HEK293 Cell Line | EDJ-KQ6908 | Human | 10131 | Details Get a Quote |
| TRAP1 Knockout HCT 116 Cell Line | EDJ-KQ30163 | Human | 10131 | Details Get a Quote |
| TRAP1 Knockout A-549 Cell Line | EDJ-KQ31539 | Human | 10131 | Details Get a Quote |
| TRAP1 Knockout HeLa Cell Line | EDJ-KQ31540 | Human | 10131 | Details Get a Quote |
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