TRAM2 (Translocation Associated Membrane Protein 2)
A key component of the translocon complex involved in protein translocation across the endoplasmic reticulum membrane.
Gene Information Card
| Symbol | TRAM2 |
|---|---|
| Full Name | Translocation Associated Membrane Protein 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 6p21.1 |
| NCBI Gene ID | 9697 ncbi.nlm.nih.gov/gene/9697 |
| Ensembl ID | ENSG00000112210 |
| UniProt ID | Q15035 |
| OMIM ID | 605190 |
| HGNC ID | 20568 |
| Aliases | TRAM2, TRAM2a, TRAM2b |
Description
TRAM2 encodes a multi-pass transmembrane protein that is a component of the translocon complex at the endoplasmic reticulum (ER) membrane. It facilitates the translocation of nascent polypeptides into the ER lumen and is involved in the processing of secretory and membrane proteins. The gene is expressed in various tissues and has been implicated in cellular stress responses and certain diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in OMIM or ClinVar | Not established | No curated evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 10.2 | Medium |
| Heart | 8.9 | Medium |
| Brain | 6.3 | Low |
| Lung | 7.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 14.0 | Hepatocellular carcinoma cell line |
| HEK 293 | 11.5 | Embryonic kidney cells |
| HeLa | 9.8 | Cervical adenocarcinoma cells |
| K562 | 6.2 | Chronic myelogenous leukemia cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No documented loss-of-function mutations in human disease.
Gain of Function (GOF)
No documented gain-of-function mutations.
Dominant Negative (DN)
No documented dominant-negative mutations.
View complete mutation data：
Gene Ontology (GO)
| • endoplasmic reticulum (GO:0005783) | • signal sequence binding (GO:0005048) |
| • SRP-dependent cotranslational protein targeting to membrane (GO:0006616) | • integral component of membrane (GO:0016021) |
Pathways
• Protein processing in endoplasmic reticulum (Reactome: R-HSA-901042)
• Cotranslational protein targeting to membrane (Reactome: R-HSA-1799339)
Protein Summary
TRAM2 is a 374-amino acid transmembrane protein localized to the endoplasmic reticulum. It contains multiple transmembrane domains and is part of the translocon complex, interacting with the Sec61 channel to facilitate protein translocation. The protein is ubiquitously expressed and plays a role in the early steps of secretory pathway.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRAM2 Knockout HEK293 Cell Line | EDJ-KQ6697 | Human | 9697 | Details Get a Quote |
| TRAM2 Knockout HCT 116 Cell Line | EDJ-KQ31053 | Human | 9697 | Details Get a Quote |
| TRAM2 Knockout HeLa Cell Line | EDJ-KQ31054 | Human | 9697 | Details Get a Quote |
| TRAM2 Knockout A-549 Cell Line | EDJ-KQ29695 | Human | 9697 | Details Get a Quote |
