TRAM1L1 Gene
Translocation Associated Membrane Protein 1 Like 1
Gene Information Card
| Symbol | TRAM1L1 |
|---|---|
| Full Name | Translocation Associated Membrane Protein 1 Like 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 4q26 |
| NCBI Gene ID | 100128731 ncbi.nlm.nih.gov/gene/100128731 |
| Ensembl ID | ENSG00000204310 |
| UniProt ID | Q5T8N4 |
| OMIM ID | 618006 |
| HGNC ID | 37223 |
| Aliases | TRAM1-like, TRAM1L |
Description
TRAM1L1 (Translocation Associated Membrane Protein 1 Like 1) is a protein-coding gene located on chromosome 4q26. It encodes a protein that is similar to TRAM1, which is involved in the translocation of nascent polypeptides across the endoplasmic reticulum membrane. The exact function of TRAM1L1 is not fully characterized, but it is predicted to play a role in protein transport and membrane trafficking.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease associations confirmed | Not established | No direct evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Brain | 2.1 | Low |
| Lung | 1.8 | Low |
| Liver | 1.5 | Low |
| Kidney | 1.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 3.0 | Low expression |
| HeLa | 2.5 | Low expression |
| K562 | 1.0 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic mutations reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • endoplasmic reticulum (GO:0005783) | • SRP-dependent cotranslational protein targeting to membrane (GO:0006614) |
| • integral component of membrane (GO:0016021) |
Pathways
• Protein processing in endoplasmic reticulum (KEGG: hsa04141)
Protein Summary
The TRAM1L1 protein is a predicted multi-pass membrane protein localized to the endoplasmic reticulum. It shares sequence similarity with TRAM1, which is a component of the translocon complex. TRAM1L1 may assist in the translocation of secretory and membrane proteins, though its specific substrates and physiological roles remain to be elucidated.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRAM1L1 Knockout HEK293 Cell Line | EDJ-KQ9309 | Human | 133022 | Details Get a Quote |
| TRAM1L1 Knockout A-549 Cell Line | EDJ-KQ35933 | Human | 133022 | Details Get a Quote |
| TRAM1L1 Knockout HeLa Cell Line | EDJ-KQ35934 | Human | 133022 | Details Get a Quote |
| TRAM1L1 Knockout HCT 116 Cell Line | EDJ-KQ75214 | Human | 133022 | Details Get a Quote |
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