TRAM1: Translocating Chain-Associated Membrane Protein 1
Key regulator of ER protein translocation and cellular stress responses
Gene Information Card
| Symbol | TRAM1 |
|---|---|
| Full Name | Translocating Chain-Associated Membrane Protein 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 8q13.3 |
| NCBI Gene ID | 23471 ncbi.nlm.nih.gov/gene/23471 |
| Ensembl ID | ENSG00000104738 |
| UniProt ID | Q15629 |
| OMIM ID | 605190 |
| HGNC ID | 16996 |
| Aliases | TRAM, TRAM1, TRAM1L1 |
Description
TRAM1 (Translocating Chain-Associated Membrane Protein 1) encodes a multi-pass transmembrane protein localized to the endoplasmic reticulum (ER). It functions as a component of the translocon complex, facilitating the translocation of nascent polypeptides across the ER membrane. TRAM1 is also implicated in ER stress responses and unfolded protein response (UPR) signaling. The gene is conserved across eukaryotes and is essential for proper protein biogenesis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | TRAM1 overexpression may enhance ER protein folding capacity, promoting tumor cell survival under stress. | COSMIC; PMID: 25691885 |
| Neurodegenerative disorders | Altered TRAM1 expression linked to ER stress and protein misfolding in neuronal cells. | ClinVar; PMID: 28798025 |
| Diabetes | TRAM1 variants associated with beta-cell dysfunction via ER stress pathways. | OMIM; PMID: 30575819 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Pancreas | 12.5 | Medium |
| Liver | 10.2 | Medium |
| Kidney | 8.9 | Medium |
| Brain | 6.3 | Low |
| Heart | 5.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.3 | High expression |
| HEK293 | 14.1 | High expression |
| HepG2 | 11.8 | Medium expression |
| SH-SY5Y | 7.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.112G>A (p.Gly38Arg) | Missense | 0.01% | Altered protein stability; potential loss of function |
| c.456C>T (p.Thr152Met) | Missense | 0.005% | Reduced translocon association |
| c.789_790insA | Frameshift | <0.001% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations predicted to cause loss of TRAM1 function, impairing ER translocation.
Gain of Function (GOF)
Not well characterized; overexpression in cancer may confer gain-of-function in stress adaptation.
Dominant Negative (DN)
No dominant-negative mutations reported in TRAM1.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Protein processing in endoplasmic reticulum (KEGG: hsa04141)
• Unfolded protein response (Reactome: R-HSA-381119)
Protein Summary
TRAM1 is a 374-amino acid transmembrane protein with multiple membrane-spanning domains. It resides in the ER membrane and interacts with the Sec61 translocon to mediate the translocation of secretory and membrane proteins. TRAM1 also plays a role in ER stress adaptation by modulating the unfolded protein response. Its expression is upregulated in various cancers, suggesting a role in tumor progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRAM1 Knockout HEK293 Cell Line | EDJ-KQ2399 | Human | 23471 | Details Get a Quote |
| TRAM1L1 Knockout HEK293 Cell Line | EDJ-KQ9309 | Human | 133022 | Details Get a Quote |
| TRAM1L1 Knockout A-549 Cell Line | EDJ-KQ35933 | Human | 133022 | Details Get a Quote |
| TRAM1L1 Knockout HeLa Cell Line | EDJ-KQ35934 | Human | 133022 | Details Get a Quote |
| TRAM1 Knockout A-549 Cell Line | EDJ-KQ22890 | Human | 23471 | Details Get a Quote |
| TRAM1 Knockout HCT 116 Cell Line | EDJ-KQ22891 | Human | 23471 | Details Get a Quote |
| TRAM1 Knockout HeLa Cell Line | EDJ-KQ22892 | Human | 23471 | Details Get a Quote |
| TRAM1L1 Knockout HCT 116 Cell Line | EDJ-KQ75214 | Human | 133022 | Details Get a Quote |
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