TRAF3IP3 Gene
TRAF3 Interacting Protein 3
Gene Information Card
| Symbol | TRAF3IP3 |
|---|---|
| Full Name | TRAF3 Interacting Protein 3 |
| Gene Type | Protein coding |
| Chromosomal Location | 1q32.1 |
| NCBI Gene ID | 80342 ncbi.nlm.nih.gov/gene/80342 |
| Ensembl ID | ENSG00000117407 |
| UniProt ID | Q9Y2Q3 |
| OMIM ID | 614175 |
| HGNC ID | 30766 |
| Aliases | T3JAM, MGC12972 |
Description
TRAF3IP3 (TRAF3 Interacting Protein 3) encodes a protein that interacts with TRAF3, a key adaptor in immune signaling pathways. The protein is involved in JNK activation and may play roles in lymphocyte development and immune responses. It is also implicated in certain cancers and inflammatory conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lung Cancer | Altered expression; potential role in tumor progression | COSMIC; literature |
| Breast Cancer | Overexpression associated with poor prognosis | COSMIC; literature |
| Inflammatory Diseases | Modulation of JNK/NF-κB pathways | UniProt; literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.2 | Medium |
| Bone marrow | 8.9 | Medium |
| Lung | 4.1 | Low |
| Breast | 2.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.0 | High expression |
| Jurkat | 20.5 | High expression |
| HeLa | 6.8 | Moderate expression |
| A549 | 4.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | Missense | <0.1% | Unknown functional effect |
| c.250G>A (p.Gly84Ser) | Missense | <0.1% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
Not well characterized; potential disruption of TRAF3 binding
Gain of Function (GOF)
Not reported
Dominant Negative (DN)
Not reported
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • JNK cascade (GO:0007254) |
| • innate immune response (GO:0045087) | • cytosol (GO:0005829) |
Pathways
• JNK signaling pathway
• TRAF3-mediated signaling
Protein Summary
TRAF3IP3 is a 55 kDa protein that localizes to the cytosol and interacts with TRAF3. It modulates JNK activation and may influence immune cell signaling. The protein is expressed in lymphoid tissues and certain cancer cell lines.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRAF3IP3 Knockout HEK293 Cell Line | EDJ-KQ8779 | Human | 80342 | Details Get a Quote |
| TRAF3IP3 Knockout HeLa Cell Line | EDJ-KQ57331 | Human | 80342 | Details Get a Quote |
| TRAF3IP3 Knockout A-549 Cell Line | EDJ-KQ65837 | Human | 80342 | Details Get a Quote |
| TRAF3IP3 Knockout HCT 116 Cell Line | EDJ-KQ74262 | Human | 80342 | Details Get a Quote |
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