TRADD: TNFRSF1A Associated via Death Domain
A key adaptor protein in TNF receptor signaling and apoptosis
Gene Information Card
| Symbol | TRADD |
|---|---|
| Full Name | TNFRSF1A Associated via Death Domain |
| Gene Type | Protein coding |
| Chromosomal Location | 16q22.1 |
| NCBI Gene ID | 7167 ncbi.nlm.nih.gov/gene/7167 |
| Ensembl ID | ENSG00000102871 |
| UniProt ID | Q15628 |
| OMIM ID | 603500 |
| HGNC ID | 11994 |
| Aliases | Hs.89862, TNFRSF1A-associated death domain protein |
Description
TRADD (TNFRSF1A Associated via Death Domain) encodes a death domain-containing adaptor protein that interacts with TNF receptor 1 (TNFR1) to mediate signaling for apoptosis, NF-kB activation, and inflammation. It is a critical component of the TNFR1 signaling complex and plays roles in cell survival and death decisions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Dysregulation of TRADD-mediated apoptosis and NF-kB signaling | COSMIC; NCBI Gene |
| Inflammatory disorders | Altered TNFR1 signaling via TRADD | OMIM; NCBI Gene |
| Neurodegenerative diseases | Potential involvement in TNF-mediated neuronal death | UniProt; NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Whole blood | 8.2 | Low |
| Lymph node | 15.3 | Medium |
| Spleen | 12.1 | Medium |
| Bone marrow | 10.5 | Medium |
| Lung | 6.8 | Low |
| Liver | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 18.5 | Cervical cancer cell line |
| K-562 | 22.3 | Leukemia cell line |
| HEK 293 | 14.7 | Embryonic kidney cell line |
| A549 | 11.2 | Lung carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown |
| c.202C>T | Nonsense | <0.01% | Loss of function |
| c.415G>A | Missense | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations leading to truncated protein and impaired TNFR1 signaling.
Gain of Function (GOF)
Not well documented; potential missense variants may enhance NF-kB activation.
Dominant Negative (DN)
Some truncating mutations may interfere with wild-type TRADD function.
View complete mutation data：
Gene Ontology (GO)
Pathways
• TNF signaling pathway (KEGG: hsa04668)
• Apoptosis (KEGG: hsa04210)
• NF-kB signaling pathway (Reactome: R-HSA-73887)
Protein Summary
TRADD is a 312-amino acid adaptor protein containing a death domain. It binds to the cytoplasmic tail of TNFR1 upon ligand stimulation, recruiting downstream effectors such as FADD and TRAF2 to mediate apoptosis and NF-kB activation. It is ubiquitously expressed and essential for TNF-induced signaling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRADD Knockout HEK293 Cell Line | EDJ-KQ598 | Human | 8717 | Details Get a Quote |
| TRADD Knockout A-549 Cell Line | EDJ-KQ19040 | Human | 8717 | Details Get a Quote |
| TRADD Knockout HCT 116 Cell Line | EDJ-KQ19041 | Human | 8717 | Details Get a Quote |
| TRADD Knockout HeLa Cell Line | EDJ-KQ19042 | Human | 8717 | Details Get a Quote |
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