TPRG1L Gene - Tumor Protein p53 Regulated Gene 1 Like
Comprehensive genomic and functional annotation of TPRG1L
Gene Information Card
| Symbol | TPRG1L |
|---|---|
| Full Name | Tumor Protein p53 Regulated Gene 1 Like |
| Gene Type | Protein coding |
| Chromosomal Location | 1p36.33 |
| NCBI Gene ID | 127262 ncbi.nlm.nih.gov/gene/127262 |
| Ensembl ID | ENSG00000142611 |
| UniProt ID | Q5T0D9 |
| OMIM ID | 617126 |
| HGNC ID | 26956 |
| Aliases | MGC16384, FLJ32709 |
Description
TPRG1L (Tumor Protein p53 Regulated Gene 1 Like) is a protein-coding gene located on chromosome 1p36.33. It encodes a protein of unknown function, but it is predicted to be involved in cellular processes regulated by p53. The gene is expressed in various tissues and has been implicated in cancer through mutational and expression studies.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lung cancer | Altered expression; potential tumor suppressor role | COSMIC; NCBI Gene |
| Breast cancer | Somatic mutations and copy number alterations | COSMIC; ClinVar |
| Colorectal cancer | Downregulation observed in tumor samples | NCBI Gene; COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.3 | Low |
| Lung | 6.1 | Low |
| Breast | 4.7 | Low |
| Colon | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.2 | Moderate expression |
| HeLa | 7.8 | Low expression |
| A549 | 5.4 | Low expression |
| MCF7 | 4.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.200G>A (p.Arg67Gln) | Missense | <0.1% | Unknown; predicted benign |
| c.341C>T (p.Pro114Leu) | Missense | <0.1% | Unknown; predicted possibly damaging |
| c.487_489del (p.Phe163del) | In-frame deletion | <0.1% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • cytoplasm (GO:0005737) |
| • nucleus (GO:0005634) |
Pathways
• p53 signaling pathway (Reactome: R-HSA-3700989)
Protein Summary
The TPRG1L protein (UniProt Q5T0D9) is 244 amino acids long with a predicted molecular mass of 27.5 kDa. It contains a coiled-coil domain and is localized to the cytoplasm and nucleus. Its exact function remains unclear, but it may participate in p53-mediated cellular responses.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TPRG1L Knockout HEK293 Cell Line | EDJ-KQ9026 | Human | 127262 | Details Get a Quote |
| TPRG1L Knockout A-549 Cell Line | EDJ-KQ35464 | Human | 127262 | Details Get a Quote |
| TPRG1L Knockout HCT 116 Cell Line | EDJ-KQ35465 | Human | 127262 | Details Get a Quote |
| TPRG1L Knockout HeLa Cell Line | EDJ-KQ35466 | Human | 127262 | Details Get a Quote |
