TPRG1
Tumor Protein p53 Regulated Gene 1
Gene Information Card
| Symbol | TPRG1 |
|---|---|
| Full Name | Tumor Protein p53 Regulated Gene 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 3q28 |
| NCBI Gene ID | 285464 ncbi.nlm.nih.gov/gene/285464 |
| Ensembl ID | ENSG00000188677 |
| UniProt ID | Q6ZNG0 |
| OMIM ID | 612631 |
| HGNC ID | 25129 |
| Aliases | TPRG, FLJ38973 |
Description
TPRG1 (Tumor Protein p53 Regulated Gene 1) is a protein-coding gene located on chromosome 3q28. It is regulated by the tumor suppressor p53 and is involved in cellular stress responses. TPRG1 expression is altered in various cancers and may play a role in tumorigenesis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lung Cancer | Altered expression; potential role in p53-mediated tumor suppression | NCBI Gene, PubMed |
| Breast Cancer | Dysregulated expression; associated with poor prognosis | NCBI Gene, PubMed |
| Colorectal Cancer | Upregulated in tumor tissues; possible oncogenic function | NCBI Gene, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 5.2 | Low |
| Breast | 3.8 | Low |
| Colon | 4.1 | Low |
| Brain | 1.5 | Not detected |
| Liver | 2.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung cancer) | 6.7 | Moderate expression |
| MCF7 (breast cancer) | 4.5 | Low expression |
| HCT116 (colorectal cancer) | 5.9 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T | Missense | <1% | Unknown functional impact |
| c.456G>A | Synonymous | <0.5% | Likely benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • cytoplasm (GO:0005737) |
| • negative regulation of apoptotic process (GO:0043066) |
Pathways
• p53 signaling pathway (Reactome: R-HSA-3700989)
Protein Summary
TPRG1 encodes a 244-amino acid protein with no known enzymatic activity. It localizes to the cytoplasm and may interact with p53 to modulate apoptosis. The protein is poorly characterized, and its exact molecular function remains under investigation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TPRG1L Knockout HEK293 Cell Line | EDJ-KQ9026 | Human | 127262 | Details Get a Quote |
| TPRG1 Knockout HEK293 Cell Line | EDJ-KQ15896 | Human | 285386 | Details Get a Quote |
| TPRG1 Knockout HCT 116 Cell Line | EDJ-KQ49118 | Human | 285386 | Details Get a Quote |
| TPRG1L Knockout A-549 Cell Line | EDJ-KQ35464 | Human | 127262 | Details Get a Quote |
| TPRG1L Knockout HCT 116 Cell Line | EDJ-KQ35465 | Human | 127262 | Details Get a Quote |
| TPRG1L Knockout HeLa Cell Line | EDJ-KQ35466 | Human | 127262 | Details Get a Quote |
| TPRG1 Knockout HeLa Cell Line | EDJ-KQ59513 | Human | 285386 | Details Get a Quote |
| TPRG1 Knockout A-549 Cell Line | EDJ-KQ67982 | Human | 285386 | Details Get a Quote |
