TPPP Gene - Tubulin Polymerization Promoting Protein
A comprehensive biomedical resource for TPPP gene, including genomic data, expression, mutations, and associated diseases.
Gene Information Card
| Symbol | TPPP |
|---|---|
| Full Name | Tubulin Polymerization Promoting Protein |
| Gene Type | protein-coding |
| Chromosomal Location | 5p15.33 |
| NCBI Gene ID | 11076 ncbi.nlm.nih.gov/gene/11076 |
| Ensembl ID | ENSG00000113580 |
| UniProt ID | O94811 |
| OMIM ID | 608773 |
| HGNC ID | 20764 |
| Aliases | p25, p25alpha, TPPP1 |
Description
TPPP (Tubulin Polymerization Promoting Protein) encodes a protein that promotes microtubule polymerization and stabilization. It is primarily expressed in the brain and is involved in the formation of abnormal protein aggregates in neurodegenerative diseases such as multiple system atrophy (MSA).
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Multiple System Atrophy | TPPP protein is a major component of glial cytoplasmic inclusions, contributing to neurodegeneration through aberrant protein aggregation. | PMID: 15009638 |
| Parkinson's Disease | TPPP interacts with alpha-synuclein, promoting its aggregation and contributing to Lewy body formation. | PMID: 17984093 |
| Prostate Cancer | TPPP overexpression is associated with tumor progression and poor prognosis. | PMID: 21573172 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 45.2 | High |
| Testis | 3.1 | Low |
| Lung | 0.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y | 12.5 | Neuronal cell line |
| HeLa | 0.2 | Low expression |
| HEK293 | 0.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown |
| c.124G>A | missense | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
Overexpression of TPPP is associated with increased microtubule polymerization and protein aggregation.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • microtubule polymerization | • protein binding |
| • tubulin binding |
Pathways
• Microtubule polymerization
• Alpha-synuclein aggregation
Protein Summary
The TPPP protein (also known as p25alpha) is a 219-amino acid protein that promotes microtubule polymerization and bundling. It is highly expressed in oligodendrocytes and neurons, and its aggregation is a hallmark of multiple system atrophy. TPPP interacts with alpha-synuclein and tubulin, influencing cytoskeletal dynamics and protein aggregation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TPPP Knockout HEK293 Cell Line | EDJ-KQ7273 | Human | 11076 | Details Get a Quote |
| TPPP2 Knockout HEK293 Cell Line | EDJ-KQ8158 | Human | 122664 | Details Get a Quote |
| TPPP3 Knockout HEK293 Cell Line | EDJ-KQ11185 | Human | 51673 | Details Get a Quote |
| TPPP Knockout HeLa Cell Line | EDJ-KQ30915 | Human | 11076 | Details Get a Quote |
| TPPP Knockout A-549 Cell Line | EDJ-KQ32293 | Human | 11076 | Details Get a Quote |
| TPPP Knockout HCT 116 Cell Line | EDJ-KQ32294 | Human | 11076 | Details Get a Quote |
| TPPP3 Knockout A-549 Cell Line | EDJ-KQ39229 | Human | 51673 | Details Get a Quote |
| TPPP3 Knockout HeLa Cell Line | EDJ-KQ39230 | Human | 51673 | Details Get a Quote |
| TPPP2 Knockout HeLa Cell Line | EDJ-KQ58102 | Human | 122664 | Details Get a Quote |
| TPPP2 Knockout A-549 Cell Line | EDJ-KQ66590 | Human | 122664 | Details Get a Quote |
| TPPP3 Knockout HCT 116 Cell Line | EDJ-KQ73279 | Human | 51673 | Details Get a Quote |
| TPPP2 Knockout HCT 116 Cell Line | EDJ-KQ75006 | Human | 122664 | Details Get a Quote |
