TP53TG3 Gene: Function, Expression, and Disease Associations | Biomedical SEO

TP53TG3 (TP53 target gene 3) is a protein-coding gene located on chromosome 16p11.2. It is one of several genes regulated by the tumor suppressor p53, which plays a central role in cellular stress responses, DNA repair, and apoptosis. The gene is part of a duplicated region on chromosome 16, giving rise to multiple paralogs (TP53TG3B, TP53TG3C). TP53TG3 expression is induced by p53 in response to DNA damage, and its protein product is thought to be involved in cell cycle regulation and apoptosis. Aberrant expression of TP53TG3 has been observed in various cancers, suggesting a potential role in tumorigenesis, though its exact molecular function remains under investigation.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• p53 signaling pathway (KEGG: hsa04115)

• Apoptosis (KEGG: hsa04210)

• Cellular senescence (KEGG: hsa04218)

The TP53TG3 protein is a small, largely uncharacterized protein of approximately 200 amino acids. It is localized to the cytoplasm and is induced by p53 upon DNA damage. The protein contains no known functional domains, but it is predicted to be involved in protein-protein interactions. Its exact role in apoptosis and cell cycle regulation is still under study, but it is believed to act as a downstream effector of p53, potentially modulating the balance between cell survival and death. The presence of multiple paralogs suggests functional redundancy or tissue-specific roles.