TOMM34: Translocase of Outer Mitochondrial Membrane 34
A mitochondrial import receptor involved in protein translocation and cancer biology
Gene Information Card
| Symbol | TOMM34 |
|---|---|
| Full Name | Translocase of Outer Mitochondrial Membrane 34 |
| Gene Type | Protein coding |
| Chromosomal Location | 20q13.12 |
| NCBI Gene ID | 10953 ncbi.nlm.nih.gov/gene/10953 |
| Ensembl ID | ENSG00000101282 |
| UniProt ID | Q15785 |
| OMIM ID | 608261 |
| HGNC ID | 15743 |
| Aliases | TOM34, URCC3, HTOM34P |
Description
TOMM34 encodes a 34 kDa component of the translocase of the outer mitochondrial membrane (TOM) complex. The protein functions as a receptor for mitochondrial preproteins, facilitating their import into the mitochondria. It is involved in the recognition and translocation of cytosolic precursor proteins, particularly those with N-terminal mitochondrial targeting signals. TOMM34 is overexpressed in various cancers and has been implicated in cell proliferation and tumorigenesis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Overexpression of TOMM34 promotes cell proliferation and invasion; associated with poor prognosis | PMID: 23444231 |
| Hepatocellular carcinoma | Upregulation correlates with tumor progression and metastasis | PMID: 25636060 |
| Breast cancer | High expression linked to aggressive tumor subtypes and reduced survival | PMID: 27323851 |
| Gastric cancer | TOMM34 overexpression enhances cell growth and migration | PMID: 28266564 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 12.5 | Medium |
| Liver | 8.3 | Low |
| Kidney | 15.2 | Medium |
| Brain | 6.1 | Low |
| Colon | 18.7 | Medium |
| Breast | 9.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 22.1 | Cervical cancer cell line |
| HepG2 | 19.8 | Hepatocellular carcinoma cell line |
| MCF7 | 16.4 | Breast cancer cell line |
| A549 | 14.2 | Lung cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.287A>G (p.Asn96Ser) | Missense | 0.01% | Unknown functional impact |
| c.512C>T (p.Pro171Leu) | Missense | 0.005% | Reported in COSMIC; potential loss of function |
| c.739G>A (p.Gly247Arg) | Missense | 0.002% | Rare variant; no clinical significance |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in TOMM34.
Gain of Function (GOF)
Overexpression in cancers suggests potential gain-of-function role in tumorigenesis.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • mitochondrion (GO:0005739) | • mitochondrial outer membrane (GO:0005741) |
| • integral component of membrane (GO:0016021) | • protein transmembrane transporter activity (GO:0005049) |
| • protein targeting to mitochondrion (GO:0006626) | • protein transport (GO:0015031) |
Pathways
• Mitochondrial protein import (Reactome: R-HSA-1268020)
• TOM complex assembly (Reactome: R-HSA-1268021)
Protein Summary
TOMM34 is a 34 kDa transmembrane protein located in the outer mitochondrial membrane. It acts as a receptor for cytosolic preproteins, recognizing N-terminal mitochondrial targeting signals and facilitating their translocation through the TOM complex. The protein contains tetratricopeptide repeat (TPR) domains that mediate interactions with chaperones and precursor proteins. TOMM34 is highly expressed in several cancers and is considered a potential biomarker and therapeutic target.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TOMM34 Knockout HEK293 Cell Line | EDJ-KQ2887 | Human | 10953 | Details Get a Quote |
| TOMM34 Knockout A-549 Cell Line | EDJ-KQ23957 | Human | 10953 | Details Get a Quote |
| TOMM34 Knockout HCT 116 Cell Line | EDJ-KQ23958 | Human | 10953 | Details Get a Quote |
| TOMM34 Knockout HeLa Cell Line | EDJ-KQ22585 | Human | 10953 | Details Get a Quote |
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