TOB1: Transducer of ERBB2, 1
A tumor suppressor gene involved in cell cycle regulation and TGF-beta signaling
Gene Information Card
| Symbol | TOB1 |
|---|---|
| Full Name | Transducer of ERBB2, 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 17q21.33 |
| NCBI Gene ID | 10140 ncbi.nlm.nih.gov/gene/10140 |
| Ensembl ID | ENSG00000141232 |
| UniProt ID | P50616 |
| OMIM ID | 605523 |
| HGNC ID | 11979 |
| Aliases | TOB, APRO5, TROB1, MGC34446 |
Description
TOB1 (Transducer of ERBB2, 1) encodes a member of the TOB/BTG family of anti-proliferative proteins. The protein interacts with ERBB2 and is involved in cell cycle regulation, particularly in the G1/S transition. It also participates in TGF-beta signaling by interacting with SMAD proteins. TOB1 is considered a tumor suppressor, with reduced expression observed in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lung cancer | Reduced TOB1 expression correlates with poor prognosis; loss of growth suppression | PMID: 15696293 |
| Breast cancer | TOB1 downregulation promotes proliferation and metastasis | PMID: 19680224 |
| Colorectal cancer | TOB1 inhibits Wnt signaling; decreased expression linked to tumor progression | PMID: 21947006 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Breast | 8.3 | Low |
| Colon | 15.2 | Medium |
| Brain | 6.1 | Low |
| Liver | 10.7 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung cancer) | 14.0 | Moderate expression |
| MCF7 (breast cancer) | 7.5 | Low expression |
| HCT116 (colorectal cancer) | 18.3 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <1% | Likely loss of start codon |
| c.214C>T (p.Arg72Trp) | Missense | <1% | Unknown significance |
| c.487_488del (p.Leu163fs) | Frameshift | <1% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations that truncate the protein, impairing anti-proliferative activity.
Gain of Function (GOF)
Not reported in TOB1.
Dominant Negative (DN)
Not reported in TOB1.
View complete mutation data：
Gene Ontology (GO)
Pathways
• TGF-beta signaling pathway (KEGG: hsa04350)
• ErbB signaling pathway (KEGG: hsa04012)
• Cell cycle (KEGG: hsa04110)
Protein Summary
TOB1 is a 345-amino acid protein with a conserved N-terminal domain (TOB domain) and a C-terminal region that mediates interactions with ERBB2 and SMAD proteins. It functions as a transcriptional co-repressor, inhibiting cell cycle progression by regulating cyclin D1 and c-Myc expression. The protein is ubiquitously expressed and shuttles between the nucleus and cytoplasm.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TOB1 Knockout HEK293 Cell Line | EDJ-KQ50934 | Human | 10140 | Details Get a Quote |
| TOB1 Knockout HeLa Cell Line | EDJ-KQ55326 | Human | 10140 | Details Get a Quote |
| TOB1 Knockout A-549 Cell Line | EDJ-KQ63809 | Human | 10140 | Details Get a Quote |
| TOB1 Knockout HCT 116 Cell Line | EDJ-KQ72268 | Human | 10140 | Details Get a Quote |
