TNS2 Gene - Tensin 2
A comprehensive guide to TNS2, encoding tensin-2, a focal adhesion protein involved in cell signaling and cytoskeletal organization.
Gene Information Card
| Symbol | TNS2 |
|---|---|
| Full Name | Tensin 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 12q13.13 |
| NCBI Gene ID | 23353 ncbi.nlm.nih.gov/gene/23353 |
| Ensembl ID | ENSG00000111206 |
| UniProt ID | Q63HR2 |
| OMIM ID | 607717 |
| HGNC ID | 11974 |
| Aliases | TENC1, C1 domain-containing phosphatase and tensin homolog, tensin-2 |
Description
TNS2 encodes tensin-2, a member of the tensin family of focal adhesion proteins. Tensin-2 contains a C1 domain, a phosphatase domain, and an SH2 domain, and is involved in cell adhesion, migration, and signal transduction. It interacts with integrins and actin cytoskeleton, playing roles in tumor suppression and kidney function.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Focal segmental glomerulosclerosis (FSGS) | Loss of TNS2 function disrupts podocyte adhesion and slit diaphragm integrity, leading to proteinuria and glomerular scarring. | ClinVar, OMIM |
| Cancer (various types) | Altered TNS2 expression or mutations affect cell migration and invasion; potential tumor suppressor role in breast, lung, and colorectal cancers. | COSMIC, NCBI |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Kidney | 15.2 | Medium |
| Liver | 10.8 | Medium |
| Lung | 8.5 | Low |
| Breast | 6.3 | Low |
| Colon | 5.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 12.4 | Embryonic kidney cells |
| HepG2 | 9.7 | Liver cancer cell line |
| A549 | 7.2 | Lung adenocarcinoma cells |
| MCF7 | 5.8 | Breast cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1375C>T (p.Arg459*) | Nonsense | Rare | Loss of function; associated with FSGS |
| c.2023G>A (p.Gly675Arg) | Missense | Rare | Potential impact on SH2 domain function |
| c.2845_2846del (p.Glu949fs) | Frameshift | Rare | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations in TNS2 lead to truncated or absent protein, impairing focal adhesion signaling and podocyte function.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in TNS2.
Dominant Negative (DN)
Not established for TNS2.
View complete mutation data：
Gene Ontology (GO)
| • focal adhesion | • actin cytoskeleton |
| • cell migration | • phosphatase activity |
| • signal transduction | • integrin binding |
Pathways
• Focal adhesion (KEGG: hsa04510)
• Integrin signaling pathway
• Actin cytoskeleton regulation
Protein Summary
Tensins are focal adhesion proteins that link integrins to the actin cytoskeleton and regulate cell signaling. Tensin-2 (TNS2) contains a C1 domain, a phosphatase domain, and an SH2 domain. It is expressed in kidney, liver, and lung, and is implicated in podocyte function and cancer cell migration. Loss-of-function mutations cause focal segmental glomerulosclerosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TNS2 Knockout HEK293 Cell Line | EDJ-KQ7994 | Human | 23371 | Details Get a Quote |
| TNS2 Knockout A-549 Cell Line | EDJ-KQ33726 | Human | 23371 | Details Get a Quote |
| TNS2 Knockout HCT 116 Cell Line | EDJ-KQ33727 | Human | 23371 | Details Get a Quote |
| TNS2 Knockout HeLa Cell Line | EDJ-KQ33728 | Human | 23371 | Details Get a Quote |
