TNS1 (Tensin 1) Gene
Cytoskeletal protein involved in cell adhesion, migration, and signaling
Gene Information Card
| Symbol | TNS1 |
|---|---|
| Full Name | Tensin 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 2q35 |
| NCBI Gene ID | 7145 ncbi.nlm.nih.gov/gene/7145 |
| Ensembl ID | ENSG00000115956 |
| UniProt ID | Q9HBL0 |
| OMIM ID | 600076 |
| HGNC ID | 11973 |
| Aliases | TNS, MST091, MST122, MST127, MSTP091, MSTP122, MSTP127 |
Description
TNS1 encodes tensin 1, a focal adhesion protein that links actin filaments to the extracellular matrix via integrin receptors. It plays a critical role in cell adhesion, migration, proliferation, and signal transduction. Tensin 1 contains SH2 and PTB domains, enabling interactions with phosphorylated tyrosine residues and signaling molecules.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered TNS1 expression affects focal adhesion dynamics and cell migration, promoting metastasis | PMID: 23454728 |
| Colorectal cancer | TNS1 downregulation correlates with poor prognosis and increased invasive potential | PMID: 25605248 |
| Cardiovascular disease | TNS1 variants associated with arterial stiffness and hypertension | PMID: 27841880 |
| Nephrotic syndrome | TNS1 mutations disrupt podocyte adhesion, leading to proteinuria | PMID: 28886344 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Kidney | 12.5 | Medium |
| Heart | 9.8 | Medium |
| Lung | 7.2 | Low |
| Breast | 6.1 | Low |
| Colon | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.3 | Embryonic kidney cells |
| MCF7 | 8.7 | Breast cancer cell line |
| HCT116 | 6.2 | Colorectal carcinoma cell line |
| A549 | 5.9 | Lung carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.187C>T (p.Arg63Trp) | Missense | 0.001% | Loss of actin-binding function |
| c.1234G>A (p.Gly412Arg) | Missense | 0.002% | Impaired focal adhesion localization |
| c.2155_2156del (p.Glu719fs) | Frameshift | <0.001% | Premature truncation, loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations that truncate the protein, disrupting actin-binding and SH2 domains.
Gain of Function (GOF)
Not well documented; no common gain-of-function variants reported.
Dominant Negative (DN)
Missense mutations in the actin-binding domain may interfere with wild-type tensin 1 function.
View complete mutation data：
Gene Ontology (GO)
| • actin binding | • focal adhesion |
| • cell-matrix adhesion | • signal transduction |
| • cytoskeleton organization | • integrin-mediated signaling pathway |
Pathways
• Focal adhesion (KEGG: hsa04510)
• ECM-receptor interaction (KEGG: hsa04512)
• Integrin signaling pathway (Reactome: R-HSA-354192)
Protein Summary
Tensin 1 is a 1,735-amino-acid protein localized to focal adhesions. It contains an N-terminal actin-binding domain, a central region with SH2 and PTB domains, and a C-terminal region. It interacts with integrins, FAK, and paxillin, regulating cell adhesion and migration. Phosphorylation at tyrosine residues modulates its signaling functions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TNS1 Knockout HEK293 Cell Line | EDJ-KQ5954 | Human | 7145 | Details Get a Quote |
| TNS1 Knockout A-549 Cell Line | EDJ-KQ29510 | Human | 7145 | Details Get a Quote |
| TNS1 Knockout HCT 116 Cell Line | EDJ-KQ29511 | Human | 7145 | Details Get a Quote |
| TNS1 Knockout HeLa Cell Line | EDJ-KQ29512 | Human | 7145 | Details Get a Quote |
| Tns1 Knockout NIH 3T3 Cell Line | EDJ-KZ56 | Mouse | 21961 | Details Get a Quote |
