TNR (Tenascin R) Gene
Extracellular Matrix Glycoprotein in Neural Development and Disease
Gene Information Card
| Symbol | TNR |
|---|---|
| Full Name | Tenascin R |
| Gene Type | protein-coding |
| Chromosomal Location | 1q25.1 |
| NCBI Gene ID | 7143 ncbi.nlm.nih.gov/gene/7143 |
| Ensembl ID | ENSG00000116194 |
| UniProt ID | Q92752 |
| OMIM ID | 601995 |
| HGNC ID | 11952 |
| Aliases | TN-R, tenascin-R, janusin, restrictin |
Description
TNR encodes tenascin R, an extracellular matrix glycoprotein predominantly expressed in the central nervous system. It plays a role in neural cell adhesion, migration, and axon guidance, and is involved in synaptic plasticity and myelination. TNR is implicated in neurodevelopmental disorders and certain cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Schizophrenia | Altered TNR expression may disrupt extracellular matrix signaling in the brain, affecting synaptic function. | PMID: 21743477 |
| Glioma | TNR overexpression in gliomas promotes tumor cell migration and invasion via integrin-mediated pathways. | PMID: 19164557 |
| Multiple Sclerosis | TNR is upregulated in demyelinating lesions and may inhibit remyelination by affecting oligodendrocyte precursor cell adhesion. | PMID: 15758027 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | High |
| Spinal Cord | 8.3 | Medium |
| Testis | 1.2 | Low |
| Heart | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 15.0 | High expression |
| U87MG (glioblastoma) | 22.3 | Very high expression |
| HEK293 (embryonic kidney) | 0.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Cys) | Missense | <0.01% | Unknown functional impact |
| c.567delA (p.Glu190fs) | Frameshift | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.567delA) likely lead to truncated protein and loss of extracellular matrix function.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • extracellular region (GO:0005576) | • cell adhesion (GO:0007155) |
| • nervous system development (GO:0007399) | • extracellular matrix organization (GO:0030198) |
| • protein binding (GO:0005515) |
Pathways
• ECM-receptor interaction (KEGG: hsa04512)
• Focal adhesion (KEGG: hsa04510)
• PI3K-Akt signaling pathway (KEGG: hsa04151)
Protein Summary
Tenascin R is a 1359-amino-acid extracellular matrix glycoprotein with a molecular weight of approximately 150 kDa. It contains EGF-like repeats, fibronectin type III domains, and a fibrinogen-like domain. It forms hexamers and interacts with integrins and other ECM components to modulate cell adhesion and migration in neural tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TNR Knockout HEK293 Cell Line | EDJ-KQ877 | Human | 7143 | Details Get a Quote |
| MTNR1B Knockout HEK293 Cell Line | EDJ-KQ2282 | Human | 4544 | Details Get a Quote |
| MTNR1A Knockout HEK293 Cell Line | EDC07578 | Human | 4543 | Details Get a Quote |
| TNRC6B Knockout HEK293 Cell Line | EDJ-KQ7841 | Human | 23112 | Details Get a Quote |
| TNRC6A Knockout HEK293 Cell Line | EDJ-KQ8762 | Human | 27327 | Details Get a Quote |
| TNRC18 Knockout HEK293 Cell Line | EDJ-KQ10138 | Human | 84629 | Details Get a Quote |
| TNRC6C Knockout HEK293 Cell Line | EDJ-KQ15086 | Human | 57690 | Details Get a Quote |
| TNRC6A Knockout A-549 Cell Line | EDJ-KQ35023 | Human | 27327 | Details Get a Quote |
| TNRC6A Knockout HCT 116 Cell Line | EDJ-KQ35024 | Human | 27327 | Details Get a Quote |
| TNRC6A Knockout HeLa Cell Line | EDJ-KQ35025 | Human | 27327 | Details Get a Quote |
| TNRC18 Knockout HCT 116 Cell Line | EDJ-KQ36009 | Human | 84629 | Details Get a Quote |
| TNRC6C Knockout A-549 Cell Line | EDJ-KQ49096 | Human | 57690 | Details Get a Quote |
| TNRC6C Knockout HCT 116 Cell Line | EDJ-KQ49097 | Human | 57690 | Details Get a Quote |
| TNRC6B Knockout A-549 Cell Line | EDJ-KQ33391 | Human | 23112 | Details Get a Quote |
| TNRC6B Knockout HCT 116 Cell Line | EDJ-KQ33392 | Human | 23112 | Details Get a Quote |
Displaying Records 1 To 15 Of 28 Records
