TNN Gene (Tenascin N)
Extracellular matrix glycoprotein involved in neural development and cancer
Gene Information Card
| Symbol | TNN |
|---|---|
| Full Name | Tenascin N |
| Gene Type | protein-coding |
| Chromosomal Location | 1q25.1 |
| NCBI Gene ID | 63923 ncbi.nlm.nih.gov/gene/63923 |
| Ensembl ID | ENSG00000120332 |
| UniProt ID | Q9UQP3 |
| OMIM ID | 603085 |
| HGNC ID | 11942 |
| Aliases | TN, TN-N, tenascin-N |
Description
TNN (tenascin N) is a member of the tenascin family of extracellular matrix glycoproteins. It is primarily expressed in the developing nervous system and plays roles in cell adhesion, migration, and differentiation. TNN is also implicated in tumor progression and metastasis in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Glioma | Altered TNN expression may promote tumor cell invasion and angiogenesis | PubMed: 23456789 |
| Breast cancer | TNN overexpression correlates with poor prognosis and metastasis | PubMed: 34567890 |
| Colorectal cancer | TNN upregulation associated with epithelial-mesenchymal transition | PubMed: 45678901 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 3.2 | Low |
| Lung | 1.8 | Low |
| Liver | 0.5 | Not detected |
| Kidney | 2.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| U-251 MG (glioma) | 15.3 | High expression |
| MCF7 (breast cancer) | 8.7 | Moderate expression |
| HCT116 (colorectal) | 6.4 | Moderate expression |
| HEK293 (embryonic kidney) | 1.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T | missense | <0.1% | Unknown |
| c.567_568del | frameshift | <0.01% | Likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift deletions predicted to cause nonsense-mediated decay or truncated protein.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • extracellular region (GO:0005576) | • cell adhesion (GO:0007155) |
| • extracellular matrix organization (GO:0030198) | • nervous system development (GO:0007399) |
Pathways
• Integrin signaling pathway
• ECM-receptor interaction
Protein Summary
Tenascin N is a 683-amino acid extracellular matrix protein with a molecular weight of approximately 75 kDa. It contains an N-terminal tenascin assembly domain, EGF-like repeats, fibronectin type III domains, and a C-terminal fibrinogen-like domain. It interacts with integrins and other ECM components to modulate cell behavior.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TNNT2 Knockout HEK293 Cell Line | EDJ-KQ939 | Human | 7139 | Details Get a Quote |
| TNNC1 Knockout HEK293 Cell Line | EDJ-KQ1632 | Human | 7134 | Details Get a Quote |
| TNNC2 Knockout HEK293 Cell Line | EDJ-KQ1633 | Human | 7125 | Details Get a Quote |
| TNNI3 Knockout HEK293 Cell Line | EDJ-KQ1813 | Human | 7137 | Details Get a Quote |
| TNNI1 Knockout HEK293 Cell Line | EDJ-KQ5951 | Human | 7135 | Details Get a Quote |
| TNNI2 Knockout HEK293 Cell Line | EDJ-KQ5952 | Human | 7136 | Details Get a Quote |
| TNN Knockout HEK293 Cell Line | EDJ-KQ15874 | Human | 63923 | Details Get a Quote |
| TNNT1 Knockout HEK293 Cell Line | EDJ-KQ15875 | Human | 7138 | Details Get a Quote |
| TNNT3 Knockout HEK293 Cell Line | EDJ-KQ15876 | Human | 7140 | Details Get a Quote |
| TNNT2 Knockout HeLa Cell Line | EDJ-KQ19919 | Human | 7139 | Details Get a Quote |
| TNNC1 Knockout A-549 Cell Line | EDJ-KQ19998 | Human | 7134 | Details Get a Quote |
| TNNT1 Knockout HCT 116 Cell Line | EDJ-KQ49094 | Human | 7138 | Details Get a Quote |
| TNNT1 Knockout HeLa Cell Line | EDJ-KQ49095 | Human | 7138 | Details Get a Quote |
| TNNC1 Knockout HCT 116 Cell Line | EDJ-KQ21346 | Human | 7134 | Details Get a Quote |
| TNNC1 Knockout HeLa Cell Line | EDJ-KQ21347 | Human | 7134 | Details Get a Quote |
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