TNK1: Tyrosine Kinase Non-Receptor 1
A non-receptor tyrosine kinase involved in cell signaling and potential tumor suppression.
Gene Information Card
| Symbol | TNK1 |
|---|---|
| Full Name | Tyrosine Kinase Non-Receptor 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 17p13.1 |
| NCBI Gene ID | 8711 ncbi.nlm.nih.gov/gene/8711 |
| Ensembl ID | ENSG00000108406 |
| UniProt ID | Q13470 |
| OMIM ID | 604127 |
| HGNC ID | 11976 |
| Aliases | TNK1, FLJ10761, MGC138290 |
Description
TNK1 (Tyrosine Kinase Non-Receptor 1) encodes a non-receptor tyrosine kinase that belongs to the ACK family. It is involved in intracellular signal transduction pathways, including regulation of cell growth, differentiation, and apoptosis. TNK1 has been implicated as a potential tumor suppressor in certain cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | Potential tumor suppressor; loss of expression may promote tumorigenesis | PMID: 23431129 |
| Colorectal cancer | Downregulation observed; may affect cell proliferation | PMID: 25263555 |
| Breast cancer | Altered expression linked to poor prognosis | PMID: 27323850 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.2 | Medium |
| Bone marrow | 8.9 | Medium |
| Lung | 4.3 | Low |
| Liver | 3.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.0 | Embryonic kidney cells |
| K562 | 22.3 | Chronic myelogenous leukemia |
| HepG2 | 6.7 | Hepatocellular carcinoma |
| MCF7 | 4.5 | Breast cancer |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1012C>T (p.Arg338Trp) | Missense | 0.01% | Unknown functional effect |
| c.1456G>A (p.Glu486Lys) | Missense | 0.005% | Potential loss of function |
| c.1789_1790insA | Frameshift | 0.001% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations predicted to truncate the kinase domain, reducing catalytic activity.
Gain of Function (GOF)
Not well documented; no recurrent activating mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects in current literature.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Signaling by Receptor Tyrosine Kinases (Reactome: R-HSA-9006934)
• Adaptive Immune System (Reactome: R-HSA-1280218)
Protein Summary
TNK1 is a 661-amino acid non-receptor tyrosine kinase containing an N-terminal kinase domain, a SH3 domain, and a C-terminal proline-rich region. It localizes to the cytoplasm and nucleus, and is involved in signal transduction from cell surface receptors. TNK1 may negatively regulate cell growth and survival, with loss of expression observed in several cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TNK1 Knockout HEK293 Cell Line | EDJ-KQ3477 | Human | 8711 | Details Get a Quote |
| TNK1 Knockout A-549 Cell Line | EDJ-KQ25244 | Human | 8711 | Details Get a Quote |
| TNK1 Knockout HCT 116 Cell Line | EDJ-KQ25245 | Human | 8711 | Details Get a Quote |
| TNK1 Knockout HeLa Cell Line | EDJ-KQ25246 | Human | 8711 | Details Get a Quote |
