TNFSF8 (CD30 Ligand)
Tumor Necrosis Factor Superfamily Member 8
Gene Information Card
| Symbol | TNFSF8 |
|---|---|
| Full Name | Tumor Necrosis Factor Superfamily Member 8 |
| Gene Type | protein-coding |
| Chromosomal Location | 9q33.1 |
| NCBI Gene ID | 944 ncbi.nlm.nih.gov/gene/944 |
| Ensembl ID | ENSG00000106991 |
| UniProt ID | P32971 |
| OMIM ID | 603875 |
| HGNC ID | 11924 |
| Aliases | CD30L, CD153, TNLG8A |
Description
TNFSF8 (Tumor Necrosis Factor Superfamily Member 8) encodes CD30 ligand (CD30L), a type II transmembrane glycoprotein belonging to the tumor necrosis factor (TNF) family. CD30L binds to CD30 (TNFRSF8) and regulates cell proliferation, differentiation, and apoptosis, particularly in lymphoid cells. It is involved in immune responses and has been implicated in Hodgkin lymphoma, anaplastic large cell lymphoma, and other inflammatory conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hodgkin lymphoma | CD30L-CD30 signaling promotes survival and proliferation of Hodgkin and Reed-Sternberg cells via NF-κB activation. | ClinVar, OMIM |
| Anaplastic large cell lymphoma | CD30L overexpression contributes to autocrine/paracrine growth stimulation in ALCL cells. | COSMIC, NCBI Gene |
| Primary cutaneous anaplastic large cell lymphoma | CD30L-CD30 interaction drives malignant transformation in cutaneous T-cell lymphomas. | OMIM, ClinVar |
| Systemic lupus erythematosus | Elevated soluble CD30L levels correlate with disease activity and B-cell activation. | NCBI Gene, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.2 | Medium |
| Thymus | 8.9 | Medium |
| Bone marrow | 6.3 | Low |
| Lung | 2.1 | Low |
| Liver | 1.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Jurkat (T-cell leukemia) | 15.8 | High expression |
| Raji (Burkitt lymphoma) | 9.4 | Medium expression |
| HEK293 (embryonic kidney) | 0.5 | Low expression |
| K562 (chronic myeloid leukemia) | 3.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.487C>T (p.Arg163Trp) | Missense | <0.1% | Unknown functional effect; rare variant in population databases |
| c.602A>G (p.Asn201Ser) | Missense | <0.1% | Reported in lymphoma samples; potential impact on receptor binding |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in TNFSF8.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported; overexpression is more common in disease.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • cytokine activity | • tumor necrosis factor receptor binding |
| • membrane | • integral component of membrane |
| • positive regulation of NF-κB transcription factor activity | • positive regulation of cell proliferation |
| • immune response | • apoptotic process |
Pathways
• TNF signaling pathway (KEGG: hsa04668)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
• NF-kappa B signaling pathway (KEGG: hsa04064)
Protein Summary
CD30 ligand (CD30L) is a 234-amino acid type II transmembrane protein with a C-terminal extracellular TNF homology domain. It forms homotrimers and binds to CD30 (TNFRSF8) on the surface of activated T cells, B cells, and Hodgkin/Reed-Sternberg cells. CD30L-CD30 interaction triggers downstream signaling via TRAF2/5 and NF-κB, leading to cell survival, proliferation, and cytokine production. Soluble CD30L is generated by proteolytic cleavage and can modulate immune responses.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TNFSF8 Knockout HEK293 Cell Line | EDJ-KQ4218 | Human | 944 | Details Get a Quote |
| TNFSF8 Knockout HeLa Cell Line | EDJ-KQ52832 | Human | 944 | Details Get a Quote |
| TNFSF8 Knockout A-549 Cell Line | EDJ-KQ61302 | Human | 944 | Details Get a Quote |
| TNFSF8 Knockout HCT 116 Cell Line | EDJ-KQ69797 | Human | 944 | Details Get a Quote |
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