TNFSF14 (TNF Superfamily Member 14)
LIGHT, a cytokine in immune regulation and cancer biology
Gene Information Card
| Symbol | TNFSF14 |
|---|---|
| Full Name | TNF Superfamily Member 14 |
| Gene Type | Protein coding |
| Chromosomal Location | 19p13.3 |
| NCBI Gene ID | 8740 ncbi.nlm.nih.gov/gene/8740 |
| Ensembl ID | ENSG00000104885 |
| UniProt ID | O43557 |
| OMIM ID | 604520 |
| HGNC ID | 11925 |
| Aliases | LIGHT, HVEM-L, CD258, LTg |
Description
TNFSF14 (TNF Superfamily Member 14), also known as LIGHT, is a cytokine belonging to the tumor necrosis factor (TNF) ligand family. It is expressed on activated T cells, natural killer cells, and immature dendritic cells. LIGHT binds to its receptors HVEM (TNFRSF14) and LTβR, playing critical roles in co-stimulation of T cells, lymphoid organogenesis, and immune homeostasis. Dysregulation of TNFSF14 is implicated in autoimmune diseases, graft-versus-host disease, and various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hodgkin lymphoma | LIGHT expressed on Reed-Sternberg cells may promote tumor immune evasion via HVEM signaling | PMID: 15692071 |
| Rheumatoid arthritis | Elevated LIGHT levels in synovial fluid contribute to inflammatory cytokine production | PMID: 12070103 |
| Inflammatory bowel disease | TNFSF14 polymorphisms associated with increased risk of Crohn's disease | PMID: 21102463 |
| Graft-versus-host disease | LIGHT blockade reduces T cell alloreactivity and GVHD severity in murine models | PMID: 11929768 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 12.5 | Medium |
| Lymph node | 10.8 | Medium |
| Bone marrow | 6.2 | Low |
| Lung | 4.1 | Low |
| Small intestine | 3.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Jurkat (T cell leukemia) | 15.2 | High expression |
| THP-1 (monocytic leukemia) | 8.7 | Moderate expression |
| HEK293 (embryonic kidney) | 2.1 | Low expression |
| K562 (chronic myeloid leukemia) | 1.5 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.346C>T (p.Arg116Trp) | Missense | <0.01% | Unknown functional effect; reported in COSMIC |
| c.487G>A (p.Gly163Ser) | Missense | <0.01% | Reported in COSMIC; no known disease association |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in TNFSF14.
Gain of Function (GOF)
No gain-of-function mutations described.
Dominant Negative (DN)
No dominant-negative variants known.
View complete mutation data：
Gene Ontology (GO)
| • tumor necrosis factor receptor binding (GO:0005164) | • immune response (GO:0006955) |
| • signal transduction (GO:0007165) | • T cell costimulation (GO:0031295) |
| • T cell activation (GO:0042110) |
Pathways
• TNF signaling pathway (KEGG: hsa04668)
• NF-kappa B signaling pathway (KEGG: hsa04064)
• LIGHT signaling via HVEM (Reactome: R-HSA-5668541)
Protein Summary
TNFSF14 encodes a 240-amino-acid type II transmembrane protein (LIGHT) with a C-terminal extracellular TNF homology domain. It forms homotrimers and binds to HVEM and LTβR. LIGHT is cleaved by metalloproteinases to generate a soluble form. The protein is involved in T cell co-stimulation, dendritic cell maturation, and lymphoid tissue development. Its dysregulation contributes to inflammatory and malignant diseases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TNFSF14 Knockout HEK293 Cell Line | EDJ-KQ597 | Human | 8740 | Details Get a Quote |
| TNFSF14 Knockout HeLa Cell Line | EDJ-KQ54994 | Human | 8740 | Details Get a Quote |
| TNFSF14 Knockout A-549 Cell Line | EDJ-KQ63477 | Human | 8740 | Details Get a Quote |
| TNFSF14 Knockout HCT 116 Cell Line | EDJ-KQ71945 | Human | 8740 | Details Get a Quote |
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