TNFRSF19
TNF Receptor Superfamily Member 19
Gene Information Card
| Symbol | TNFRSF19 |
|---|---|
| Full Name | TNF Receptor Superfamily Member 19 |
| Gene Type | protein-coding |
| Chromosomal Location | 13q12.12 |
| NCBI Gene ID | 55504 ncbi.nlm.nih.gov/gene/55504 |
| Ensembl ID | ENSG00000127863 |
| UniProt ID | Q9NP84 |
| OMIM ID | 606122 |
| HGNC ID | 11915 |
| Aliases | TAJ, TROY, TAJ-alpha, TRADE |
Description
TNFRSF19 encodes a member of the tumor necrosis factor receptor superfamily. The protein is a type I transmembrane receptor that activates NF-kappaB and JNK signaling pathways. It is involved in embryonic development, cell survival, and inflammation. Expression is detected in various tissues, including brain, skin, and reproductive organs.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hereditary sensory and autonomic neuropathy type I (HSAN1) | Missense mutations in TNFRSF19 impair receptor signaling, leading to neuronal degeneration. | ClinVar, OMIM |
| Squamous cell carcinoma | Overexpression of TNFRSF19 (TROY) promotes tumor growth and invasion via NF-kB activation. | COSMIC, PubMed |
| Ovarian cancer | TNFRSF19 upregulation correlates with poor prognosis and chemoresistance. | COSMIC, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Skin | 8.3 | Low |
| Testis | 15.2 | Medium |
| Ovary | 6.7 | Low |
| Lung | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.2 | Embryonic kidney cells |
| HeLa | 7.8 | Cervical cancer cells |
| A549 | 5.3 | Lung carcinoma cells |
| MCF7 | 3.9 | Breast cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.226C>T (p.Arg76Cys) | Missense | <0.01% | Impaired receptor activation; associated with HSAN1 |
| c.487G>A (p.Gly163Ser) | Missense | 0.02% | Reduced NF-kB signaling |
| c.1021_1023del (p.Leu341del) | Deletion | <0.01% | Loss of function in vitro |
Mutation functional classification
Loss of Function (LOF)
Missense mutations (e.g., p.Arg76Cys) reduce receptor signaling and are linked to HSAN1.
Gain of Function (GOF)
Overexpression in cancers leads to constitutive NF-kB activation.
Dominant Negative (DN)
Not reported for TNFRSF19.
View complete mutation data：
Gene Ontology (GO)
| • receptor activity | • NF-kappaB-inducing kinase activity |
| • tumor necrosis factor-activated receptor activity | • signal transduction |
| • apoptotic process | • positive regulation of JNK cascade |
Pathways
• TNF signaling pathway (KEGG: hsa04668)
• NF-kappa B signaling pathway (KEGG: hsa04064)
• Apoptosis (KEGG: hsa04210)
Protein Summary
TNFRSF19 is a 430-amino acid transmembrane receptor with an extracellular cysteine-rich domain and an intracellular death domain. It binds to TRAF2 and TRAF5 to activate NF-kB and JNK pathways. The protein is implicated in neural development, inflammation, and cancer progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TNFRSF19 Knockout HEK293 Cell Line | EDJ-KQ2209 | Human | 55504 | Details Get a Quote |
| TNFRSF19 Knockout HeLa Cell Line | EDJ-KQ21159 | Human | 55504 | Details Get a Quote |
| TNFRSF19 Knockout A-549 Cell Line | EDJ-KQ22467 | Human | 55504 | Details Get a Quote |
| TNFRSF19 Knockout HCT 116 Cell Line | EDJ-KQ73535 | Human | 55504 | Details Get a Quote |
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