TMOD3 (Tropomodulin 3)
Actin-capping protein involved in cytoskeletal regulation and potential cancer biomarker
Gene Information Card
| Symbol | TMOD3 |
|---|---|
| Full Name | Tropomodulin 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 15q21.2 |
| NCBI Gene ID | 29766 ncbi.nlm.nih.gov/gene/29766 |
| Ensembl ID | ENSG00000138592 |
| UniProt ID | Q9NYL9 |
| OMIM ID | 605116 |
| HGNC ID | 11873 |
| Aliases | UTMOD, U-Tmod |
Description
TMOD3 encodes tropomodulin 3, a member of the tropomodulin family of actin-capping proteins. It binds to the pointed ends of actin filaments, regulating actin filament length and dynamics. TMOD3 is widely expressed and plays roles in cell morphology, motility, and cytoskeletal organization. Altered expression has been implicated in cancer progression and metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression of TMOD3 promotes cell migration and invasion via actin cytoskeleton remodeling | PMID: 25944712 |
| Hepatocellular carcinoma | Upregulation correlates with poor prognosis and enhanced metastatic potential | PMID: 28407145 |
| Colorectal cancer | TMOD3 knockdown reduces cell proliferation and invasion in vitro | PMID: 29393419 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 12.3 | Medium |
| Liver | 8.7 | Medium |
| Kidney | 10.1 | Medium |
| Lung | 6.5 | Low |
| Brain | 4.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 15.2 | High expression |
| HepG2 (liver cancer) | 11.8 | Moderate expression |
| A549 (lung cancer) | 7.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.472C>T (p.Arg158Trp) | Missense | <0.01% | Unknown functional impact |
| c.625G>A (p.Gly209Ser) | Missense | <0.01% | Reported in COSMIC as somatic variant |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
Overexpression in cancers suggests potential gain-of-function role in tumor progression.
Dominant Negative (DN)
Not documented.
View complete mutation data：
Gene Ontology (GO)
| • actin filament capping | • actin cytoskeleton organization |
| • regulation of actin filament length | • cell migration |
| • cytoplasm |
Pathways
• Actin cytoskeleton regulation (Reactome: R-HSA-5663213)
• Tropomodulin-mediated actin dynamics
Protein Summary
Tropomodulin 3 is a 352-amino acid protein that caps the pointed ends of actin filaments, preventing elongation and depolymerization. It contains a tropomyosin-binding domain and an actin-binding domain. The protein is ubiquitously expressed and is involved in maintaining cytoskeletal integrity, cell shape, and motility. Dysregulation is linked to cancer metastasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TMOD3 Knockout HEK293 Cell Line | EDJ-KQ2053 | Human | 29766 | Details Get a Quote |
| TMOD3 Knockout A-549 Cell Line | EDJ-KQ22114 | Human | 29766 | Details Get a Quote |
| TMOD3 Knockout HCT 116 Cell Line | EDJ-KQ22115 | Human | 29766 | Details Get a Quote |
| TMOD3 Knockout HeLa Cell Line | EDJ-KQ20821 | Human | 29766 | Details Get a Quote |
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