TMF1 (TATA Element Modulatory Factor 1)
A Golgin Protein Involved in Golgi Structure, Androgen Receptor Signaling, and Potential Tumor Suppression
Gene Information Card
| Symbol | TMF1 |
|---|---|
| Full Name | TATA element modulatory factor 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 3p13 |
| NCBI Gene ID | 7110 ncbi.nlm.nih.gov/gene/7110 |
| Ensembl ID | ENSG00000144747 |
| UniProt ID | P82094 |
| OMIM ID | 603019 |
| HGNC ID | 11870 |
| Aliases | ARA160, TMF, TMF1_HUMAN |
Description
TMF1 (TATA element modulatory factor 1) encodes a Golgi-associated protein (golgin) that plays a role in maintaining Golgi structure and vesicle trafficking. It also functions as a coactivator of the androgen receptor (AR) and has been implicated in transcriptional regulation. TMF1 is considered a potential tumor suppressor in certain cancers, with loss or downregulation observed in prostate and other malignancies.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | TMF1 (ARA160) acts as an androgen receptor coactivator; altered expression may influence AR signaling and tumor progression. | PMID: 10887107; NCBI Gene |
| Breast cancer | Reduced TMF1 expression has been reported in breast cancer cell lines, suggesting a possible tumor suppressor role. | COSMIC; PMID: 23382219 |
| Colorectal cancer | Somatic mutations and copy number loss of TMF1 have been identified in colorectal tumors. | COSMIC; ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Prostate | 8.2 | Medium |
| Breast | 6.1 | Low |
| Colon | 5.8 | Low |
| Liver | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 7.0 | Cervical cancer cell line |
| MCF7 | 5.2 | Breast cancer cell line |
| LNCaP | 9.1 | Prostate cancer cell line |
| HCT116 | 6.5 | Colorectal cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <0.1% | Loss of function; predicted to cause nonsense-mediated decay |
| c.567_568insA (p.Glu190fs) | Frameshift | <0.1% | Loss of function; truncated protein |
| c.2101G>A (p.Gly701Arg) | Missense | <0.1% | Unknown significance; may affect Golgi localization |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations in TMF1 are predicted to result in loss of function, potentially disrupting Golgi integrity and AR coactivation.
Gain of Function (GOF)
No gain-of-function mutations have been reported for TMF1.
Dominant Negative (DN)
No dominant-negative mutations have been characterized for TMF1.
View complete mutation data：
Gene Ontology (GO)
| • Golgi apparatus | • Golgi membrane |
| • protein binding | • androgen receptor binding |
| • Golgi organization | • vesicle-mediated transport |
| • intracellular protein transport |
Pathways
• Androgen receptor signaling pathway
• Golgi vesicle transport
Protein Summary
TMF1 is a 1098-amino acid golgin protein localized to the Golgi apparatus. It contains a coiled-coil domain and a TATA element modulatory domain. TMF1 is involved in maintaining Golgi ribbon structure, retrograde transport, and acts as a coactivator of the androgen receptor. Its loss is associated with Golgi fragmentation and altered AR signaling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TMF1 Knockout HEK293 Cell Line | EDJ-KQ5942 | Human | 7110 | Details Get a Quote |
| TMF1 Knockout A-549 Cell Line | EDJ-KQ29494 | Human | 7110 | Details Get a Quote |
| TMF1 Knockout HCT 116 Cell Line | EDJ-KQ29495 | Human | 7110 | Details Get a Quote |
| TMF1 Knockout HeLa Cell Line | EDJ-KQ29496 | Human | 7110 | Details Get a Quote |
