TMEM92: Transmembrane Protein 92
A little-characterized transmembrane protein with potential roles in cancer and immune signaling
Gene Information Card
| Symbol | TMEM92 |
|---|---|
| Full Name | Transmembrane Protein 92 |
| Gene Type | Protein coding |
| Chromosomal Location | 17q21.33 |
| NCBI Gene ID | 221468 ncbi.nlm.nih.gov/gene/221468 |
| Ensembl ID | ENSG00000186919 |
| UniProt ID | Q6ZMR5 |
| OMIM ID | 618419 |
| HGNC ID | 28300 |
| Aliases | MGC131831, MGC14836, FLJ38973 |
Description
TMEM92 (Transmembrane Protein 92) is a protein-coding gene located on chromosome 17q21.33. The encoded protein is predicted to be a multi-pass membrane protein, but its exact biological function remains largely uncharacterized. Preliminary studies suggest involvement in immune signaling and potential roles in cancer progression, including breast and colorectal cancers. Expression data indicate enrichment in immune tissues and certain cancer cell lines.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Potential oncogenic role; overexpression observed in tumor tissues | NCBI Gene, PubMed (limited) |
| Colorectal cancer | Altered expression linked to tumor progression | NCBI Gene, PubMed (limited) |
| Immune-related disorders | Possible involvement in immune signaling pathways | UniProt, literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.2 | Medium |
| Bone marrow | 8.7 | Low |
| Lung | 6.3 | Low |
| Breast | 4.1 | Low |
| Colon | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 15.2 | Moderate expression |
| HCT116 (colorectal cancer) | 12.8 | Moderate expression |
| K562 (leukemia) | 9.5 | Low expression |
| HEK293 (embryonic kidney) | 6.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown functional impact |
| c.45C>T | Synonymous | <0.01% | No predicted effect |
| c.78G>A | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • integral component of membrane (GO:0016021) | • plasma membrane (GO:0005886) |
Pathways
• No curated pathways available
Protein Summary
TMEM92 encodes a 292-amino acid transmembrane protein with multiple predicted membrane-spanning domains. The protein is localized to the plasma membrane and may function in cell signaling or adhesion. Its precise molecular role is not yet defined, but expression patterns suggest involvement in immune system processes and cancer biology.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TMEM92 Knockout HEK293 Cell Line | EDJ-KQ15783 | Human | 162461 | Details Get a Quote |
| TMEM92 Knockout A-549 Cell Line | EDJ-KQ48971 | Human | 162461 | Details Get a Quote |
| TMEM92 Knockout HCT 116 Cell Line | EDJ-KQ48972 | Human | 162461 | Details Get a Quote |
| TMEM92 Knockout HeLa Cell Line | EDJ-KQ48973 | Human | 162461 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
