TMEM91: Transmembrane Protein 91
A poorly characterized transmembrane protein with potential roles in cellular signaling and disease.
Gene Information Card
| Symbol | TMEM91 |
|---|---|
| Full Name | Transmembrane Protein 91 |
| Gene Type | Protein coding |
| Chromosomal Location | 19q13.42 |
| NCBI Gene ID | 641649 ncbi.nlm.nih.gov/gene/641649 |
| Ensembl ID | ENSG00000188385 |
| UniProt ID | Q5BJF2 |
| OMIM ID | - |
| HGNC ID | HGNC:37223 |
| Aliases | MGC16384, FLJ39653 |
Description
TMEM91 (Transmembrane Protein 91) is a protein-coding gene located on chromosome 19q13.42. The encoded protein is predicted to contain transmembrane domains, suggesting a role in membrane-associated processes. Currently, its specific biological function is not well characterized, but expression data indicate potential involvement in cellular signaling or transport. Limited studies suggest possible links to cancer and other diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Altered expression may contribute to tumorigenesis; specific mechanism unknown. | Expression data from COSMIC and literature. |
| - | - | - |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Brain | 2.1 | Low |
| Lung | 1.8 | Low |
| Kidney | 1.5 | Low |
| Liver | 1.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 3.4 | Low expression |
| HeLa | 2.1 | Low expression |
| K562 | 1.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Unknown |
| c.205G>A (p.Gly69Ser) | Missense | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • integral component of membrane |
Protein Summary
TMEM91 is a 91-amino acid transmembrane protein with a single predicted transmembrane helix. Its exact function remains unknown, but it is localized to cellular membranes. Expression is low across most tissues, with highest levels in testis. No significant structural domains have been identified beyond the transmembrane region.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TMEM91 Knockout HEK293 Cell Line | EDJ-KQ12177 | Human | 641649 | Details Get a Quote |
| TMEM91 Knockout A-549 Cell Line | EDJ-KQ40891 | Human | 641649 | Details Get a Quote |
| TMEM91 Knockout HCT 116 Cell Line | EDJ-KQ40892 | Human | 641649 | Details Get a Quote |
| TMEM91 Knockout HeLa Cell Line | EDJ-KQ40893 | Human | 641649 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
