TMEM87A
Transmembrane Protein 87A
Gene Information Card
| Symbol | TMEM87A |
|---|---|
| Full Name | Transmembrane Protein 87A |
| Gene Type | Protein coding |
| Chromosomal Location | 15q25.2 |
| NCBI Gene ID | 25963 ncbi.nlm.nih.gov/gene/25963 |
| Ensembl ID | ENSG00000137819 |
| UniProt ID | Q8NBN3 |
| OMIM ID | 616000 |
| HGNC ID | 26122 |
| Aliases | FLJ10156, MGC131738 |
Description
TMEM87A encodes a transmembrane protein of unknown function. It is predicted to be a multi-pass membrane protein localized to the Golgi apparatus and endosomes. The gene is conserved in eukaryotes and may play a role in vesicle trafficking or cell signaling.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 10.2 | Medium |
| Heart | 8.5 | Medium |
| Liver | 6.1 | Low |
| Kidney | 7.3 | Low |
| Testis | 12.4 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 9.8 | RNA-seq data |
| HeLa | 7.5 | RNA-seq data |
| K562 | 6.2 | RNA-seq data |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Cys) | Missense | <0.01% | Unknown functional impact |
| c.567G>A (p.Val189Ile) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported
Gain of Function (GOF)
No confirmed gain-of-function variants reported
Dominant Negative (DN)
No evidence of dominant-negative effects
View complete mutation data：
Gene Ontology (GO)
| • Golgi apparatus | • integral component of membrane |
| • endosome |
Pathways
• No curated pathways available
Protein Summary
TMEM87A is a 553-amino acid multi-pass transmembrane protein with unknown function. It is predicted to localize to the Golgi and endosomal membranes. No enzymatic activity or binding partners have been experimentally validated.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TMEM87A Knockout HEK293T Cell Line | EDJ-KQ237 | Human | 25963 | Details Get a Quote |
| TMEM87A Knockout HEK293 Cell Line | EDJ-KQ2459 | Human | 25963 | Details Get a Quote |
| TMEM87A Knockout A-549 Cell Line | EDJ-KQ24380 | Human | 25963 | Details Get a Quote |
| TMEM87A Knockout HCT 116 Cell Line | EDJ-KQ24382 | Human | 25963 | Details Get a Quote |
| TMEM87A Knockout HeLa Cell Line | EDJ-KQ24383 | Human | 25963 | Details Get a Quote |
