TMEM81: Transmembrane Protein 81
A gene encoding a transmembrane protein with potential roles in cellular signaling and cancer.
Gene Information Card
| Symbol | TMEM81 |
|---|---|
| Full Name | Transmembrane Protein 81 |
| Gene Type | Protein-coding |
| Chromosomal Location | 1q32.1 |
| NCBI Gene ID | 388730 ncbi.nlm.nih.gov/gene/388730 |
| Ensembl ID | ENSG00000186205 |
| UniProt ID | Q6P7N7 |
| OMIM ID | 617478 |
| HGNC ID | 28308 |
| Aliases | MGC24039, FLJ32709 |
Description
TMEM81 (Transmembrane Protein 81) is a protein-coding gene located on chromosome 1q32.1. The encoded protein is predicted to be a multi-pass transmembrane protein, though its exact biological function remains under investigation. TMEM81 is expressed in various tissues and has been implicated in certain cancers based on expression and mutation data.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Altered expression and somatic mutations may contribute to tumorigenesis | COSMIC, ClinVar |
| Lung adenocarcinoma | Overexpression observed in tumor samples | NCBI GEO profiles |
| Colorectal cancer | Somatic mutations reported | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Thyroid | 8.2 | Low |
| Prostate | 6.1 | Low |
| Lung | 5.4 | Low |
| Breast | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.3 | Highest in kidney-derived line |
| A549 | 7.1 | Lung carcinoma |
| MCF7 | 5.6 | Breast cancer |
| HCT116 | 4.9 | Colorectal carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.347G>A (p.Arg116Gln) | Missense | <0.1% | Unknown |
| c.523C>T (p.Arg175Trp) | Missense | <0.1% | Unknown |
| c.788_789insA | Frameshift | <0.01% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.788_789insA) are predicted to cause loss of function.
Gain of Function (GOF)
No evidence for gain-of-function mutations.
Dominant Negative (DN)
No evidence for dominant-negative mutations.
View complete mutation data：
Gene Ontology (GO)
| • integral component of membrane (GO:0016021) | • plasma membrane (GO:0005886) |
Pathways
• No curated pathways available
Protein Summary
TMEM81 is a 281-amino acid transmembrane protein with multiple membrane-spanning domains. Its precise function is unknown, but it is predicted to localize to the plasma membrane and may be involved in cell-cell communication or transport. Expression data suggest a role in normal testis and thyroid function, with aberrant expression in some cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TMEM81 Knockout HEK293 Cell Line | EDJ-KQ15779 | Human | 388730 | Details Get a Quote |
| TMEM81 Knockout A-549 Cell Line | EDJ-KQ48968 | Human | 388730 | Details Get a Quote |
| TMEM81 Knockout HCT 116 Cell Line | EDJ-KQ48969 | Human | 388730 | Details Get a Quote |
| TMEM81 Knockout HeLa Cell Line | EDJ-KQ48970 | Human | 388730 | Details Get a Quote |
