TMEM68: Transmembrane Protein 68
A gene encoding a transmembrane protein with potential roles in lipid metabolism and cellular signaling.
Gene Information Card
| Symbol | TMEM68 |
|---|---|
| Full Name | Transmembrane Protein 68 |
| Gene Type | protein-coding |
| Chromosomal Location | 8q21.13 |
| NCBI Gene ID | 137695 ncbi.nlm.nih.gov/gene/137695 |
| Ensembl ID | ENSG00000167978 |
| UniProt ID | Q5T4S7 |
| OMIM ID | 618142 |
| HGNC ID | 26007 |
| Aliases | MGC13170, FLJ22662 |
Description
TMEM68 (Transmembrane Protein 68) is a protein-coding gene located on chromosome 8q21.13. The encoded protein is predicted to be a multi-pass transmembrane protein with unknown function, though it may be involved in lipid metabolism based on sequence similarity and expression patterns. Expression is observed in various tissues, with highest levels in the liver and kidney.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease associations | Not established | No curated evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 8.3 | Medium |
| Testis | 6.1 | Low |
| Brain | 4.2 | Low |
| Heart | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 10.2 | Liver cancer cell line |
| HEK293 | 7.5 | Embryonic kidney cells |
| K562 | 5.0 | Leukemia cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown |
| c.100C>T | synonymous | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No known loss-of-function mutations reported.
Gain of Function (GOF)
No known gain-of-function mutations reported.
Dominant Negative (DN)
No known dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • integral component of membrane | • membrane |
Pathways
• No curated pathways
Protein Summary
TMEM68 is a 237-amino acid transmembrane protein with multiple membrane-spanning domains. Its exact function is unknown, but it is predicted to localize to the endoplasmic reticulum or plasma membrane. No enzymatic activity or binding partners have been experimentally validated.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TMEM68 Knockout HEK293 Cell Line | EDJ-KQ2616 | Human | 137695 | Details Get a Quote |
| TMEM68 Knockout HCT 116 Cell Line | EDJ-KQ21974 | Human | 137695 | Details Get a Quote |
| TMEM68 Knockout A-549 Cell Line | EDJ-KQ23340 | Human | 137695 | Details Get a Quote |
| TMEM68 Knockout HeLa Cell Line | EDJ-KQ23342 | Human | 137695 | Details Get a Quote |
