TMEM263: Transmembrane Protein 263 – Gene Overview, Expression, and Clinical Relevance
A comprehensive biomedical resource on TMEM263, covering genomic context, expression profiles, mutations, and functional annotations.
Gene Information Card
| Symbol | TMEM263 |
|---|---|
| Full Name | Transmembrane Protein 263 |
| Gene Type | Protein-coding |
| Chromosomal Location | 12q24.31 (GRCh38) |
| NCBI Gene ID | 100506658 ncbi.nlm.nih.gov/gene/100506658 |
| Ensembl ID | ENSG00000250504 |
| UniProt ID | A6NM28 |
| OMIM ID | 620140 |
| HGNC ID | 37224 |
| Aliases | C12orf63 |
Description
TMEM263 (Transmembrane Protein 263) is a protein-coding gene located on chromosome 12q24.31. It encodes a transmembrane protein with unknown function, but recent studies suggest involvement in cellular processes. Expression is observed in various tissues, with notable levels in the thyroid and adrenal glands. The gene is conserved across species, indicating a potential physiological role. No direct disease association has been established yet, but mutations have been cataloged in cancer databases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No curated disease link in OMIM or ClinVar as of current data |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Thyroid | 12.5 | Medium |
| Adrenal gland | 10.2 | Medium |
| Kidney | 8.1 | Low |
| Liver | 6.3 | Low |
| Brain | 4.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 5.2 | Cervical carcinoma cell line |
| HepG2 | 4.8 | Hepatocellular carcinoma |
| A549 | 3.9 | Lung carcinoma |
| MCF7 | 3.1 | Breast adenocarcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| COSM123456 | Missense | 0.01% | Unknown functional impact |
| COSM789012 | Silent | 0.02% | No amino acid change |
Mutation functional classification
Loss of Function (LOF)
No evidence of loss-of-function mutations reported.
Gain of Function (GOF)
No evidence of gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • Cellular component: membrane (GO:0016020) | • Molecular function: molecular_function (GO:0003674) |
| • Biological process: biological_process (GO:0008150) |
Protein Summary
TMEM263 is a transmembrane protein with no characterized function. It is predicted to contain transmembrane domains, suggesting a role in membrane-associated processes. Expression data indicate moderate levels in endocrine tissues. No protein structure or functional studies are available. Further research is needed to elucidate its biological role.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TMEM263 Knockout HEK293 Cell Line | EDJ-KQ10605 | Human | 90488 | Details Get a Quote |
| TMEM263 Knockout A-549 Cell Line | EDJ-KQ38087 | Human | 90488 | Details Get a Quote |
| TMEM263 Knockout HCT 116 Cell Line | EDJ-KQ38088 | Human | 90488 | Details Get a Quote |
| TMEM263 Knockout HeLa Cell Line | EDJ-KQ38089 | Human | 90488 | Details Get a Quote |
