TMEM187
Transmembrane Protein 187
Gene Information Card
| Symbol | TMEM187 |
|---|---|
| Full Name | Transmembrane Protein 187 |
| Gene Type | protein-coding |
| Chromosomal Location | 17q21.31 |
| NCBI Gene ID | 8269 ncbi.nlm.nih.gov/gene/8269 |
| Ensembl ID | ENSG00000167996 |
| UniProt ID | Q96BQ1 |
| OMIM ID | 616183 |
| HGNC ID | 28746 |
| Aliases | MGC12966, PRO1877 |
Description
TMEM187 encodes a transmembrane protein of unknown function. It is predicted to be a component of cellular membranes, but its specific biological role and substrates have not been characterized. Expression data suggest broad tissue distribution.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No curated evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 5.2 | Low |
| Heart | 3.8 | Low |
| Liver | 2.1 | Low |
| Kidney | 4.5 | Low |
| Lung | 3.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 4.0 | Low expression |
| HeLa | 3.5 | Low expression |
| K562 | 2.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • integral component of membrane |
Protein Summary
TMEM187 is a 187-amino acid transmembrane protein with no known enzymatic or signaling function. Its structure includes a single transmembrane domain, but functional studies are lacking.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TMEM187 Knockout HEK293 Cell Line | EDJ-KQ105 | Human | 8269 | Details Get a Quote |
| TMEM187 Knockout A-549 Cell Line | EDJ-KQ49019 | Human | 8269 | Details Get a Quote |
| TMEM187 Knockout HeLa Cell Line | EDJ-KQ49020 | Human | 8269 | Details Get a Quote |
| TMEM187 Knockout HCT 116 Cell Line | EDJ-KQ46799 | Human | 8269 | Details Get a Quote |
| TMEM187 Knockout K-562 Cell Line | EDJ-KZ512 | Human | 8269 | Details Get a Quote |
