TMEM186: Transmembrane Protein 186
A poorly characterized transmembrane protein with limited functional annotation.
Gene Information Card
| Symbol | TMEM186 |
|---|---|
| Full Name | Transmembrane Protein 186 |
| Gene Type | Protein coding |
| Chromosomal Location | 16p13.3 |
| NCBI Gene ID | 25880 ncbi.nlm.nih.gov/gene/25880 |
| Ensembl ID | ENSG00000161921 |
| UniProt ID | Q96B77 |
| OMIM ID | 617782 |
| HGNC ID | 28487 |
| Aliases | MGC13170, FLJ22662 |
Description
TMEM186 is a protein-coding gene located on chromosome 16p13.3. It encodes a transmembrane protein of unknown function. The protein is predicted to localize to cellular membranes, but its biological role and associated pathways remain largely uncharacterized. Limited expression data suggest low to moderate expression in certain tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease associations established | Not applicable | No evidence in ClinVar, OMIM, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 2.1 | Low |
| Heart | 1.5 | Low |
| Liver | 0.8 | Not detected |
| Kidney | 1.2 | Low |
| Testis | 3.0 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 1.8 | Low expression |
| K562 | 0.5 | Not detected |
| HeLa | 2.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • integral component of membrane (GO:0016021) |
Protein Summary
TMEM186 is a 186-amino acid transmembrane protein with a single predicted transmembrane domain. Its function is unknown, and no protein structures have been solved. It is not associated with any known disease or pathway.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TMEM186 Knockout HEK293 Cell Line | EDJ-KQ8280 | Human | 25880 | Details Get a Quote |
| TMEM186 Knockout A-549 Cell Line | EDJ-KQ34230 | Human | 25880 | Details Get a Quote |
| TMEM186 Knockout HCT 116 Cell Line | EDJ-KQ34231 | Human | 25880 | Details Get a Quote |
| TMEM186 Knockout HeLa Cell Line | EDJ-KQ34232 | Human | 25880 | Details Get a Quote |
