TMEM181
Transmembrane Protein 181
Gene Information Card
| Symbol | TMEM181 |
|---|---|
| Full Name | Transmembrane Protein 181 |
| Gene Type | Protein coding |
| Chromosomal Location | 6q27 |
| NCBI Gene ID | 57580 ncbi.nlm.nih.gov/gene/57580 |
| Ensembl ID | ENSG00000146433 |
| UniProt ID | Q9BUN8 |
| OMIM ID | 616722 |
| HGNC ID | 28468 |
| Aliases | MGC13170, FLJ22662 |
Description
TMEM181 (Transmembrane Protein 181) is a protein-coding gene located on chromosome 6q27. It encodes a multi-pass membrane protein of unknown function. The protein is predicted to be involved in cellular signaling or transport processes based on its transmembrane domains. Expression data suggest broad but low-level expression in various tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease association | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 2.1 | Low |
| Heart | 1.5 | Low |
| Liver | 0.8 | Not detected |
| Kidney | 1.2 | Low |
| Testis | 3.4 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 1.8 | Low expression |
| HeLa | 0.9 | Not detected |
| K562 | 2.5 | Low |
| HepG2 | 1.1 | Low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • integral component of membrane | • membrane |
Protein Summary
TMEM181 is a 7-transmembrane domain protein of 661 amino acids. Its exact biological function remains uncharacterized, but it is predicted to localize to the plasma membrane or intracellular membranes. No enzymatic activity or binding partners have been experimentally validated.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TMEM181 Knockout HEK293 Cell Line | EDJ-KQ12235 | Human | 57583 | Details Get a Quote |
| TMEM181 Knockout A-549 Cell Line | EDJ-KQ40998 | Human | 57583 | Details Get a Quote |
| TMEM181 Knockout HCT 116 Cell Line | EDJ-KQ40999 | Human | 57583 | Details Get a Quote |
| TMEM181 Knockout HeLa Cell Line | EDJ-KQ41000 | Human | 57583 | Details Get a Quote |
