TMEM179: Transmembrane Protein 179
A poorly characterized transmembrane protein with potential roles in cellular signaling and disease.
Gene Information Card
| Symbol | TMEM179 |
|---|---|
| Full Name | Transmembrane Protein 179 |
| Gene Type | Protein coding |
| Chromosomal Location | 14q24.3 |
| NCBI Gene ID | 100131732 ncbi.nlm.nih.gov/gene/100131732 |
| Ensembl ID | ENSG00000204149 |
| UniProt ID | Q8N7M0 |
| OMIM ID | 617959 |
| HGNC ID | 37236 |
| Aliases | C14orf105, FLJ45831 |
Description
TMEM179 (Transmembrane Protein 179) is a protein-coding gene located on chromosome 14q24.3. It encodes a transmembrane protein of unknown function, but is predicted to be involved in cellular signaling or transport. Expression data suggest it is widely expressed in various tissues, with highest levels in the brain and testis. Limited functional studies exist, and its role in disease is not well established.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Unknown | No direct evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 3.2 | Low |
| Testis | 2.8 | Low |
| Kidney | 1.5 | Not detected |
| Liver | 0.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 1.2 | Low expression |
| HeLa | 0.9 | Low expression |
| K562 | 0.5 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • integral component of membrane (GO:0016021) |
Protein Summary
TMEM179 is a 179-amino acid transmembrane protein with a single predicted transmembrane domain. Its function is unknown, but it may be involved in cell-cell communication or membrane trafficking. No crystal structure is available.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TMEM179B Knockout HEK293 Cell Line | EDJ-KQ12234 | Human | 374395 | Details Get a Quote |
| TMEM179 Knockout HEK293 Cell Line | EDJ-KQ15806 | Human | 388021 | Details Get a Quote |
| TMEM179B Knockout A-549 Cell Line | EDJ-KQ40995 | Human | 374395 | Details Get a Quote |
| TMEM179B Knockout HCT 116 Cell Line | EDJ-KQ40996 | Human | 374395 | Details Get a Quote |
| TMEM179B Knockout HeLa Cell Line | EDJ-KQ40997 | Human | 374395 | Details Get a Quote |
| TMEM179 Knockout HeLa Cell Line | EDJ-KQ60005 | Human | 388021 | Details Get a Quote |
| TMEM179 Knockout A-549 Cell Line | EDJ-KQ68466 | Human | 388021 | Details Get a Quote |
| TMEM179 Knockout HCT 116 Cell Line | EDJ-KQ76844 | Human | 388021 | Details Get a Quote |
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