TMEM178A
Transmembrane Protein 178A
Gene Information Card
| Symbol | TMEM178A |
|---|---|
| Full Name | Transmembrane Protein 178A |
| Gene Type | protein-coding |
| Chromosomal Location | 2p23.3 |
| NCBI Gene ID | 130733 ncbi.nlm.nih.gov/gene/130733 |
| Ensembl ID | ENSG00000162998 |
| UniProt ID | Q8NBP7 |
| OMIM ID | 617351 |
| HGNC ID | 28478 |
| Aliases | MGC13017, TMEM178 |
Description
TMEM178A encodes a transmembrane protein with unknown function. It is predicted to be a multi-pass membrane protein localized to the endoplasmic reticulum or plasma membrane. Expression is observed in various tissues, with highest levels in the brain and testis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Testis | 10.2 | Medium |
| Lung | 5.1 | Low |
| Liver | 2.3 | Low |
| Heart | 1.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 8.4 | Moderate expression |
| HeLa | 6.7 | Moderate expression |
| K562 | 3.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported
Gain of Function (GOF)
No confirmed gain-of-function variants reported
Dominant Negative (DN)
No confirmed dominant-negative variants reported
View complete mutation data：
Gene Ontology (GO)
| • integral component of membrane | • membrane |
Protein Summary
TMEM178A is a 278-amino acid transmembrane protein with four predicted transmembrane helices. Its biological function remains uncharacterized, but it may play a role in cellular signaling or transport. No known protein interactions or enzymatic activity have been described.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TMEM178A Knockout HEK293 Cell Line | EDJ-KQ3449 | Human | 130733 | Details Get a Quote |
| TMEM178A Knockout HeLa Cell Line | EDJ-KQ58281 | Human | 130733 | Details Get a Quote |
| TMEM178A Knockout A-549 Cell Line | EDJ-KQ66771 | Human | 130733 | Details Get a Quote |
| TMEM178A Knockout HCT 116 Cell Line | EDJ-KQ75174 | Human | 130733 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
