TMEM171: Transmembrane Protein 171
A poorly characterized transmembrane protein with potential roles in cellular signaling and cancer.
Gene Information Card
| Symbol | TMEM171 |
|---|---|
| Full Name | Transmembrane Protein 171 |
| Gene Type | Protein coding |
| Chromosomal Location | 5q13.2 |
| NCBI Gene ID | 100130449 ncbi.nlm.nih.gov/gene/100130449 |
| Ensembl ID | ENSG00000185052 |
| UniProt ID | Q8N6L1 |
| OMIM ID | - |
| HGNC ID | 34478 |
| Aliases | MGC16384, FLJ39653 |
Description
TMEM171 (Transmembrane Protein 171) is a protein-coding gene located on chromosome 5q13.2. The encoded protein is predicted to contain transmembrane domains, suggesting a role in membrane-associated processes. Currently, its specific biological function is not well characterized, but expression data indicate potential involvement in cancer and other diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Altered expression observed in tumor tissues; specific mechanism unknown. | NCBI Gene, COSMIC |
| Breast cancer | Differential expression reported in breast cancer cell lines and tissues. | COSMIC, NCBI Gene |
| Lung cancer | Mutations and expression changes noted in lung cancer samples. | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.8 | Low |
| Thyroid | 0.6 | Low |
| Adrenal gland | 0.5 | Low |
| Brain | 0.3 | Low |
| Kidney | 0.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.5 | Low expression |
| HeLa | 0.4 | Low expression |
| MCF7 | 0.6 | Moderate expression in breast cancer line |
| A549 | 0.7 | Moderate expression in lung cancer line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.1% | Unknown |
| c.100C>T | Nonsense | <0.1% | Predicted loss of function |
| c.200_201del | Frameshift | <0.1% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations are predicted to cause loss of function.
Gain of Function (GOF)
No evidence for gain-of-function mutations.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • integral component of membrane | • membrane |
Protein Summary
TMEM171 is a 171-amino acid protein with predicted transmembrane domains. Its exact function is unknown, but it is localized to cellular membranes and may be involved in signal transduction or transport processes.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TMEM171 Knockout HEK293 Cell Line | EDJ-KQ9336 | Human | 134285 | Details Get a Quote |
| TMEM171 Knockout A-549 Cell Line | EDJ-KQ35967 | Human | 134285 | Details Get a Quote |
| TMEM171 Knockout HCT 116 Cell Line | EDJ-KQ35968 | Human | 134285 | Details Get a Quote |
| TMEM171 Knockout HeLa Cell Line | EDJ-KQ58337 | Human | 134285 | Details Get a Quote |
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