TMEM170A
Transmembrane Protein 170A: A Nuclear Envelope Component with Emerging Roles in Cellular Organization and Disease
Gene Information Card
| Symbol | TMEM170A |
|---|---|
| Full Name | Transmembrane Protein 170A |
| Gene Type | Protein coding |
| Chromosomal Location | 16q23.1 |
| NCBI Gene ID | 124923 ncbi.nlm.nih.gov/gene/124923 |
| Ensembl ID | ENSG00000140987 |
| UniProt ID | Q5T4S7 |
| OMIM ID | 617061 |
| HGNC ID | 26033 |
| Aliases | FLJ22662, MGC138290, MGC138291 |
Description
TMEM170A encodes a transmembrane protein localized to the nuclear envelope. It is involved in nuclear membrane organization and may play a role in maintaining nuclear architecture. The gene is broadly expressed in human tissues, with highest levels in the thyroid and adrenal glands. Limited functional studies suggest a potential role in cellular stress responses and cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered expression; potential role in tumor progression | Expression profiling studies (COSMIC, NCBI) |
| Prostate cancer | Underexpression observed in some cohorts | Expression data (NCBI, COSMIC) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Thyroid | 12.5 | Medium |
| Adrenal gland | 10.8 | Medium |
| Testis | 8.2 | Low |
| Lung | 6.1 | Low |
| Liver | 4.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 8.0 | Moderate expression |
| HeLa | 6.5 | Moderate expression |
| MCF7 | 5.2 | Low expression |
| A549 | 4.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.437C>T (p.Pro146Leu) | Missense | <0.01% | Unknown functional impact |
| c.682G>A (p.Glu228Lys) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • integral component of membrane | • nuclear envelope |
| • membrane |
Pathways
• No curated pathways available
Protein Summary
TMEM170A is a 305-amino-acid transmembrane protein with a single predicted transmembrane domain. It localizes to the nuclear envelope and may contribute to nuclear shape and stability. The protein is conserved in vertebrates, but its precise molecular function remains under investigation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TMEM170A Knockout HEK293 Cell Line | EDJ-KQ8569 | Human | 124491 | Details Get a Quote |
| TMEM170A Knockout A-549 Cell Line | EDJ-KQ34725 | Human | 124491 | Details Get a Quote |
| TMEM170A Knockout HCT 116 Cell Line | EDJ-KQ34726 | Human | 124491 | Details Get a Quote |
| TMEM170A Knockout HeLa Cell Line | EDJ-KQ34727 | Human | 124491 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
