TMEM164: Transmembrane Protein 164
A novel gene with potential roles in cellular signaling and disease
Gene Information Card
| Symbol | TMEM164 |
|---|---|
| Full Name | Transmembrane Protein 164 |
| Gene Type | protein-coding |
| Chromosomal Location | Xq26.3 |
| NCBI Gene ID | 114915 ncbi.nlm.nih.gov/gene/114915 |
| Ensembl ID | ENSG00000102054 |
| UniProt ID | Q5T0T0 |
| OMIM ID | 300982 |
| HGNC ID | 28470 |
| Aliases | FLJ32709, MGC131831 |
Description
TMEM164 encodes a transmembrane protein of unknown function. It is predicted to be a multi-pass membrane protein localized to the endoplasmic reticulum or Golgi apparatus. Expression data suggest roles in brain and testis, but functional studies are limited.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 2.3 | Low |
| Testis | 1.8 | Low |
| Lung | 0.5 | Not detected |
| Liver | 0.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 1.2 | Low expression |
| K562 | 0.8 | Low expression |
| HeLa | 0.6 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated variants | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
Not established
Gain of Function (GOF)
Not established
Dominant Negative (DN)
Not established
View complete mutation data：
Protein Summary
TMEM164 is a 164-amino acid transmembrane protein with no known functional domains. Its biological role remains uncharacterized, and no disease associations have been confirmed.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TMEM164 Knockout HEK293 Cell Line | EDJ-KQ10004 | Human | 84187 | Details Get a Quote |
| TMEM164 Knockout A-549 Cell Line | EDJ-KQ36976 | Human | 84187 | Details Get a Quote |
| TMEM164 Knockout HCT 116 Cell Line | EDJ-KQ36977 | Human | 84187 | Details Get a Quote |
| TMEM164 Knockout HeLa Cell Line | EDJ-KQ36978 | Human | 84187 | Details Get a Quote |
