TMEM158: Transmembrane Protein 158
A potential tumor suppressor gene involved in cell adhesion and migration
Gene Information Card
| Symbol | TMEM158 |
|---|---|
| Full Name | Transmembrane Protein 158 |
| Gene Type | Protein coding |
| Chromosomal Location | 3p21.31 |
| NCBI Gene ID | 25907 ncbi.nlm.nih.gov/gene/25907 |
| Ensembl ID | ENSG00000163932 |
| UniProt ID | Q8N2Z9 |
| OMIM ID | 617796 |
| HGNC ID | 26030 |
| Aliases | C3orf8, FLJ22662 |
Description
TMEM158 (Transmembrane Protein 158) is a protein-coding gene located on chromosome 3p21.31. It encodes a transmembrane protein with a single transmembrane domain. TMEM158 is thought to play a role in cell adhesion and migration, and has been implicated as a potential tumor suppressor in various cancers, including lung, breast, and colorectal cancer. Its expression is frequently downregulated in tumor tissues, and loss of function may contribute to cancer progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lung Cancer | Downregulation of TMEM158 may promote cell migration and invasion, suggesting a tumor suppressive role. | NCBI Gene, COSMIC |
| Breast Cancer | Reduced expression correlates with poor prognosis; potential role in metastasis suppression. | NCBI Gene, COSMIC |
| Colorectal Cancer | Frequent downregulation observed; may inhibit tumor growth and metastasis. | NCBI Gene, COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 2.3 | Low |
| Breast | 1.8 | Low |
| Colon | 3.1 | Low |
| Prostate | 2.0 | Low |
| Ovary | 1.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (Lung) | 1.2 | Low expression |
| MCF7 (Breast) | 0.9 | Low expression |
| HCT116 (Colon) | 2.5 | Moderate expression |
| PC3 (Prostate) | 1.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.1% | Unknown effect |
| c.100C>T | Nonsense | <0.1% | Predicted loss of function |
| c.200_201del | Frameshift | <0.1% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations are predicted to cause loss of function, consistent with a tumor suppressor role.
Gain of Function (GOF)
No evidence of gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • plasma membrane (GO:0005886) | • integral component of membrane (GO:0016021) |
| • cell adhesion (GO:0007155) | • cell migration (GO:0016477) |
Pathways
• No specific pathways curated in major databases.
Protein Summary
TMEM158 is a 158-amino acid transmembrane protein with a single transmembrane domain. It localizes to the plasma membrane and is involved in cell adhesion and migration. The protein is widely expressed at low levels in normal tissues, and its downregulation in several cancers suggests a tumor suppressive function. Structural studies are limited.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TMEM158 Knockout HEK293 Cell Line | EDJ-KQ8296 | Human | 25907 | Details Get a Quote |
| TMEM158 Knockout HCT 116 Cell Line | EDJ-KQ32944 | Human | 25907 | Details Get a Quote |
| TMEM158 Knockout A-549 Cell Line | EDJ-KQ34261 | Human | 25907 | Details Get a Quote |
| TMEM158 Knockout HeLa Cell Line | EDJ-KQ34262 | Human | 25907 | Details Get a Quote |
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