TMEM132B
Transmembrane Protein 132B
Gene Information Card
| Symbol | TMEM132B |
|---|---|
| Full Name | Transmembrane Protein 132B |
| Gene Type | Protein coding |
| Chromosomal Location | 12q24.33 |
| NCBI Gene ID | 114795 ncbi.nlm.nih.gov/gene/114795 |
| Ensembl ID | ENSG00000139329 |
| UniProt ID | Q14C87 |
| OMIM ID | 616866 |
| HGNC ID | 29386 |
| Aliases | KIAA1945, MGC13017 |
Description
TMEM132B encodes a transmembrane protein of unknown function. It is part of the TMEM132 family, which may be involved in cell adhesion and signaling. Expression is observed in various tissues, with highest levels in the brain and testis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No confirmed disease associations | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 15.2 | Medium |
| Testis | 12.8 | Medium |
| Lung | 5.1 | Low |
| Liver | 2.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 8.5 | Moderate expression |
| SH-SY5Y | 11.0 | Moderate expression |
| HeLa | 4.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
Not established
Gain of Function (GOF)
Not established
Dominant Negative (DN)
Not established
View complete mutation data：
Gene Ontology (GO)
| • integral component of membrane | • protein binding |
Protein Summary
TMEM132B is a 1007-amino acid transmembrane protein with a single pass membrane domain. Its function is not well characterized, but it may play a role in cell-cell interactions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TMEM132B Knockout HEK293 Cell Line | EDJ-KQ7466 | Human | 114795 | Details Get a Quote |
| TMEM132B Knockout HeLa Cell Line | EDJ-KQ57931 | Human | 114795 | Details Get a Quote |
| TMEM132B Knockout A-549 Cell Line | EDJ-KQ66421 | Human | 114795 | Details Get a Quote |
| TMEM132B Knockout HCT 116 Cell Line | EDJ-KQ74846 | Human | 114795 | Details Get a Quote |
