TMEM132A
Transmembrane Protein 132A
Gene Information Card
| Symbol | TMEM132A |
|---|---|
| Full Name | Transmembrane Protein 132A |
| Gene Type | Protein coding |
| Chromosomal Location | 11q12.2 |
| NCBI Gene ID | 54972 ncbi.nlm.nih.gov/gene/54972 |
| Ensembl ID | ENSG00000149257 |
| UniProt ID | Q8WZ55 |
| OMIM ID | 611685 |
| HGNC ID | 25434 |
| Aliases | DKFZp434B1231, FLJ12529, MGC138290 |
Description
TMEM132A encodes a transmembrane protein of unknown function. It is expressed in various tissues and may be involved in cell adhesion or signaling. Limited functional data are available.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 5.2 | Low |
| Heart | 3.1 | Low |
| Liver | 1.8 | Not detected |
| Kidney | 4.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 6.5 | Moderate expression |
| HeLa | 4.8 | Low expression |
| K562 | 2.3 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T | Missense | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
Not established
Gain of Function (GOF)
Not established
Dominant Negative (DN)
Not established
View complete mutation data：
Gene Ontology (GO)
| • integral component of membrane |
Protein Summary
TMEM132A is a 1009-amino acid transmembrane protein with no characterized domains. Its function remains largely unknown.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TMEM132A Knockout HEK293 Cell Line | EDJ-KQ3687 | Human | 54972 | Details Get a Quote |
| TMEM132A Knockout A-549 Cell Line | EDJ-KQ25687 | Human | 54972 | Details Get a Quote |
| TMEM132A Knockout HCT 116 Cell Line | EDJ-KQ25688 | Human | 54972 | Details Get a Quote |
| TMEM132A Knockout HeLa Cell Line | EDJ-KQ25689 | Human | 54972 | Details Get a Quote |
