TLE3 Gene - Transducin-Like Enhancer of Split 3
Transcriptional corepressor in the Wnt signaling pathway and cancer biology
Gene Information Card
| Symbol | TLE3 |
|---|---|
| Full Name | Transducin-Like Enhancer of Split 3 |
| Gene Type | Protein coding |
| Chromosomal Location | 15q22.31 |
| NCBI Gene ID | 7090 ncbi.nlm.nih.gov/gene/7090 |
| Ensembl ID | ENSG00000137807 |
| UniProt ID | Q04726 |
| OMIM ID | 600190 |
| HGNC ID | 11839 |
| Aliases | ESG3, GRG3, TLE3A, TLE3B |
Description
TLE3 encodes a member of the TLE (transducin-like enhancer of split) family of transcriptional corepressors. These proteins are homologs of the Drosophila Groucho protein and function by interacting with transcription factors such as TCF/LEF to repress Wnt target gene expression. TLE3 is involved in cell fate determination, differentiation, and cancer progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | TLE3 represses Wnt/β-catenin target genes; loss of TLE3 expression may enhance Wnt signaling and tumorigenesis | PMID: 19029980 |
| Breast cancer | TLE3 overexpression correlates with poor prognosis and may modulate estrogen receptor signaling | PMID: 23382212 |
| Ovarian cancer | TLE3 expression is associated with chemoresistance and epithelial-mesenchymal transition | PMID: 25695676 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 6.1 | Low |
| Lung | 9.7 | Low |
| Kidney | 11.2 | Medium |
| Colon | 14.8 | Medium |
| Breast | 10.5 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.2 | Cervical cancer cell line |
| MCF7 | 18.7 | Breast cancer cell line |
| HCT116 | 22.1 | Colorectal cancer cell line |
| A549 | 9.8 | Lung cancer cell line |
| K562 | 7.5 | Leukemia cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339*) | Nonsense | <0.1% | Truncation; likely loss of function |
| c.1423G>A (p.Gly475Arg) | Missense | <0.1% | Unknown significance |
| c.1876_1877insA | Frameshift | <0.1% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations in TLE3 are predicted to cause loss of corepressor activity, potentially derepressing Wnt target genes.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in TLE3.
Dominant Negative (DN)
No dominant-negative mutations described for TLE3.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Wnt signaling pathway (KEGG: hsa04310)
• Transcriptional misregulation in cancer (KEGG: hsa05202)
• Hippo signaling pathway (KEGG: hsa04390)
Protein Summary
TLE3 is a 781-amino-acid nuclear protein containing an N-terminal glutamine-rich domain and a C-terminal WD40 repeat domain. It functions as a transcriptional corepressor by recruiting histone deacetylases to promoter regions. TLE3 interacts with TCF/LEF transcription factors to repress Wnt/β-catenin target genes, and with other factors such as RUNX1 and PAX5. The protein is widely expressed in adult tissues and plays roles in neurogenesis, hematopoiesis, and cancer.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TLE3 Knockout HEK293 Cell Line | EDJ-KQ343 | Human | 7090 | Details Get a Quote |
| TLE3 Knockout HCT 116 Cell Line | EDJ-KQ17975 | Human | 7090 | Details Get a Quote |
| TLE3 Knockout A-549 Cell Line | EDJ-KQ18521 | Human | 7090 | Details Get a Quote |
| TLE3 Knockout HeLa Cell Line | EDJ-KQ18523 | Human | 7090 | Details Get a Quote |
