TICAM2
TIR Domain Containing Adaptor Molecule 2
Gene Information Card
| Symbol | TICAM2 |
|---|---|
| Full Name | TIR Domain Containing Adaptor Molecule 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 5q23.1 |
| NCBI Gene ID | 353376 ncbi.nlm.nih.gov/gene/353376 |
| Ensembl ID | ENSG00000164342 |
| UniProt ID | Q86XR7 |
| OMIM ID | 608052 |
| HGNC ID | 29848 |
| Aliases | TRAM, TICAM-2, MyD88-3, TIRP |
Description
TICAM2 (TIR Domain Containing Adaptor Molecule 2) encodes an adaptor protein involved in Toll-like receptor (TLR) signaling. It specifically mediates the TLR4 and TLR3 pathways by recruiting downstream effectors such as TICAM1 (TRIF) and activating IRF3 and NF-κB, leading to type I interferon production and inflammatory responses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Influenza A infection | TICAM2 mediates TLR3/4 signaling to induce antiviral interferon response; variants may alter susceptibility | PMID: 19017987 |
| Sepsis | Dysregulation of TICAM2-dependent TLR4 signaling contributes to excessive inflammation | PMID: 21536852 |
| Autoimmune diseases (e.g., systemic lupus erythematosus) | Altered TICAM2 expression may affect interferon production and autoimmunity | PMID: 23144463 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 8.6 | Medium |
| Spleen | 7.2 | Medium |
| Liver | 5.1 | Low |
| Kidney | 4.8 | Low |
| Whole blood | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 9.1 | High expression |
| THP-1 | 7.5 | Monocyte line |
| HeLa | 6.3 | Moderate expression |
| A549 | 5.8 | Lung epithelial line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.238C>T (p.Arg80Trp) | Missense | <0.01% | May impair TLR4 signaling; reported in ClinVar |
| c.454G>A (p.Val152Met) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
p.Arg80Trp may reduce adaptor function in TLR4 pathway
Gain of Function (GOF)
None reported
Dominant Negative (DN)
None reported
View complete mutation data：
Gene Ontology (GO)
| • protein binding | • signal transducer activity |
| • TIR domain binding | • innate immune response |
| • positive regulation of type I interferon production | • MyD88-independent toll-like receptor signaling pathway |
Pathways
• Toll-like receptor signaling pathway (KEGG: hsa04620)
• TRIF-mediated TLR3/TLR4 signaling (Reactome: R-HSA-166166)
• IRF3 activation (Reactome: R-HSA-933542)
Protein Summary
TICAM2 (TRAM) is a 235-amino-acid adaptor protein containing a TIR domain. It localizes to the plasma membrane and endosomes, where it bridges TLR4 and TLR3 to TICAM1 (TRIF), initiating IRF3 and NF-κB activation. It is essential for MyD88-independent TLR signaling and antiviral responses.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TICAM2 Knockout HEK293 Cell Line | EDJ-KQ15731 | Human | 353376 | Details Get a Quote |
| TICAM2 Knockout A-549 Cell Line | EDJ-KQ46647 | Human | 353376 | Details Get a Quote |
| TICAM2 Knockout HeLa Cell Line | EDJ-KQ46648 | Human | 353376 | Details Get a Quote |
| TMED7-TICAM2 Knockout HEK293 Cell Line | EDJ-KQ52449 | Human | 100302736 | Details Get a Quote |
| TMED7-TICAM2 Knockout HeLa Cell Line | EDJ-KQ60885 | Human | 100302736 | Details Get a Quote |
| TMED7-TICAM2 Knockout A-549 Cell Line | EDJ-KQ69358 | Human | 100302736 | Details Get a Quote |
| TICAM2 Knockout HCT 116 Cell Line | EDJ-KQ76717 | Human | 353376 | Details Get a Quote |
| TMED7-TICAM2 Knockout HCT 116 Cell Line | EDJ-KQ77713 | Human | 100302736 | Details Get a Quote |
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