THY1 (Thy-1 Cell Surface Antigen) Gene
A GPI-anchored glycoprotein involved in cell adhesion, signaling, and immune regulation
Gene Information Card
| Symbol | THY1 |
|---|---|
| Full Name | Thy-1 cell surface antigen |
| Gene Type | protein-coding |
| Chromosomal Location | 11q23.3 |
| NCBI Gene ID | 7070 ncbi.nlm.nih.gov/gene/7070 |
| Ensembl ID | ENSG00000154096 |
| UniProt ID | P04216 |
| OMIM ID | 188230 |
| HGNC ID | 11801 |
| Aliases | CD90, FLJ33325 |
Description
THY1 encodes a glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein, also known as CD90. It is a member of the immunoglobulin superfamily and plays roles in cell adhesion, neurite outgrowth, T-cell activation, and tumor suppression. THY1 is expressed on thymocytes, neurons, endothelial cells, and fibroblasts, and its expression is frequently lost in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (multiple types) | Loss of THY1 expression promotes epithelial-mesenchymal transition and metastasis. | NCBI Gene, COSMIC |
| Pulmonary fibrosis | Reduced THY1 on lung fibroblasts correlates with myofibroblast differentiation and fibrosis. | NCBI Gene, PubMed |
| Glomerulosclerosis | THY1 depletion in mesangial cells leads to proliferative glomerulonephritis in animal models. | OMIM, PubMed |
| Alzheimer's disease | THY1 interacts with amyloid-beta and modulates neurite degeneration. | UniProt, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Low |
| Kidney | 6.1 | Low |
| Thymus | 45.2 | High |
| Spleen | 3.4 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 0.2 | Low expression |
| Jurkat | 18.7 | High expression (T-cell line) |
| SH-SY5Y | 9.1 | Moderate expression (neuronal) |
| HepG2 | 0.5 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.1% | Likely loss of start codon; functional impact unknown |
| c.215C>T (p.Pro72Leu) | Missense | <0.1% | Rare variant; no known disease association |
Mutation functional classification
Loss of Function (LOF)
Loss of THY1 expression is common in cancers and fibrosis, leading to increased cell migration and proliferation.
Gain of Function (GOF)
Not reported; THY1 overexpression is generally tumor-suppressive.
Dominant Negative (DN)
Not described for THY1.
View complete mutation data：
Gene Ontology (GO)
| • cell adhesion (GO:0007155) | • plasma membrane (GO:0005886) |
| • signal transduction (GO:0007165) | • anchored component of membrane (GO:0046658) |
| • protein binding (GO:0005515) |
Pathways
• Integrin signaling pathway
• Focal adhesion
• T-cell receptor signaling pathway
Protein Summary
Thy-1 (CD90) is a 25-37 kDa GPI-anchored glycoprotein with a single immunoglobulin-like domain. It is expressed on thymocytes, neurons, endothelial cells, and fibroblasts. Thy-1 mediates cell-cell and cell-matrix adhesion, modulates integrin signaling, and regulates T-cell activation. Loss of Thy-1 is associated with cancer progression and fibrosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| Thy1 Knockout BV-2 Cell Line | EDJ-KQ07 | Mouse | 21838 | Details Get a Quote |
| Thy1 Knockout LL/2 (LLC1) Cell Line | EDJ-KQ52 | Mouse | 21838 | Details Get a Quote |
| Thy1 Knockout RAW 264.7 Cell Line | EDJ-KQ62 | Mouse | 21838 | Details Get a Quote |
| Thy1 Knockout C2C12 Cell Line | EDJ-KQ81 | Mouse | 21838 | Details Get a Quote |
| Thy1 Knockout DC2.4 Cell Line | EDJ-KQ83 | Mouse | 21838 | Details Get a Quote |
| Thy1 Knockout Kupffer Cell Line | EDJ-KQ87 | Mouse | 21838 | Details Get a Quote |
| THY1 Knockout HEK293 Cell Line | EDJ-KQ3830 | Human | 7070 | Details Get a Quote |
| THY1 Knockout A-549 Cell Line | EDJ-KQ25979 | Human | 7070 | Details Get a Quote |
| THY1 Knockout HeLa Cell Line | EDJ-KQ25980 | Human | 7070 | Details Get a Quote |
| THY1 Knockout HCT 116 Cell Line | EDJ-KQ71612 | Human | 7070 | Details Get a Quote |
Displaying Records 1 To 10 Of 10 Records
