TGOLN2
Trans-Golgi Network Protein 2
Gene Information Card
| Symbol | TGOLN2 |
|---|---|
| Full Name | trans-Golgi network protein 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 2p11.2 |
| NCBI Gene ID | 10618 ncbi.nlm.nih.gov/gene/10618 |
| Ensembl ID | ENSG00000115970 |
| UniProt ID | O43493 |
| OMIM ID | 605868 |
| HGNC ID | 15450 |
| Aliases | TGN46, TGN51, TGN38, TGN2 |
Description
TGOLN2 encodes a type I membrane protein localized to the trans-Golgi network (TGN). It is involved in vesicular trafficking, protein sorting, and maintenance of Golgi structure. The protein cycles between the TGN and the plasma membrane, functioning in endosome-to-TGN retrograde transport.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Altered expression may affect Golgi trafficking and cell signaling | Expression changes observed in tumor samples (COSMIC) |
| Infectious diseases | Potential role in viral entry or trafficking | Indirect evidence from protein interaction studies |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 10.2 | Medium |
| Liver | 8.5 | Medium |
| Kidney | 12.1 | Medium |
| Lung | 9.8 | Medium |
| Heart | 7.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.4 | Cervical cancer cell line |
| HEK293 | 13.2 | Embryonic kidney cells |
| A549 | 11.8 | Lung carcinoma cells |
| MCF7 | 9.6 | Breast cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234G>A | missense | 0.01% | Unknown functional impact |
| c.567_568insA | frameshift | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations may lead to truncated protein and loss of TGN localization.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • Golgi membrane | • trans-Golgi network |
| • protein transport | • vesicle-mediated transport |
| • intracellular protein transport |
Pathways
• Vesicle-mediated transport
• Golgi-to-ER retrograde transport
Protein Summary
TGOLN2 is a 46 kDa transmembrane protein predominantly localized to the trans-Golgi network. It contains a luminal domain, a transmembrane domain, and a short cytoplasmic tail with sorting motifs. The protein cycles between the TGN and the plasma membrane, participating in retrograde transport from endosomes to the TGN.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TGOLN2 Knockout HEK293 Cell Line | EDJ-KQ973 | Human | 10618 | Details Get a Quote |
| TGOLN2 Knockout A-549 Cell Line | EDJ-KQ19986 | Human | 10618 | Details Get a Quote |
| TGOLN2 Knockout HCT 116 Cell Line | EDJ-KQ19987 | Human | 10618 | Details Get a Quote |
| TGOLN2 Knockout HeLa Cell Line | EDJ-KQ19988 | Human | 10618 | Details Get a Quote |
