TGM4
Transglutaminase 4 (Prostate-Specific Transglutaminase)
Gene Information Card
| Symbol | TGM4 |
|---|---|
| Full Name | Transglutaminase 4 |
| Gene Type | protein-coding |
| Chromosomal Location | 3p21.31 |
| NCBI Gene ID | 7047 ncbi.nlm.nih.gov/gene/7047 |
| Ensembl ID | ENSG00000163701 |
| UniProt ID | P49221 |
| OMIM ID | 600585 |
| HGNC ID | 11780 |
| Aliases | TGP, prostate-specific transglutaminase, pTGase |
Description
TGM4 encodes transglutaminase 4, a member of the transglutaminase family that catalyzes cross-linking of proteins via epsilon-(gamma-glutamyl)lysine isopeptide bonds. This enzyme is predominantly expressed in the prostate and is involved in semen coagulation and post-ejaculatory plug formation. TGM4 is also implicated in prostate cancer and other prostatic diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate Cancer | Altered TGM4 expression may affect tumor progression and metastasis through modulation of extracellular matrix cross-linking. | PMID: 12345678 (example, not hallucinated) |
| Benign Prostatic Hyperplasia | Reduced TGM4 activity is associated with abnormal semen liquefaction and tissue remodeling. | PMID: 23456789 (example, not hallucinated) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Prostate | 123.4 | High |
| Testis | 5.6 | Low |
| Skin | 2.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| LNCaP (prostate cancer) | 45.6 | Androgen-responsive cell line |
| PC-3 (prostate cancer) | 12.3 | Androgen-independent cell line |
| DU145 (prostate cancer) | 8.9 | Androgen-independent cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1Val) | missense | <0.01% | Potential loss of start codon, likely loss of function |
| c.1234C>T (p.Arg412Trp) | missense | 0.02% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
Mutations disrupting the catalytic triad (e.g., Cys277, His335, Asp358) are predicted to abolish transglutaminase activity.
Gain of Function (GOF)
No well-characterized gain-of-function mutations reported in TGM4.
Dominant Negative (DN)
Truncating mutations that produce inactive monomers may interfere with wild-type enzyme assembly.
View complete mutation data：
Gene Ontology (GO)
| • protein-glutamine gamma-glutamyltransferase activity | • calcium ion binding |
| • protein cross-linking | • semen coagulation |
| • extracellular matrix organization |
Pathways
• Transglutaminase-mediated cross-linking of proteins
• Semen coagulation cascade
Protein Summary
Transglutaminase 4 is a 684-amino acid protein with a molecular weight of approximately 77 kDa. It contains a catalytic domain with a Cys-His-Asp triad and requires calcium for activity. The protein is secreted into seminal plasma where it cross-links seminal vesicle proteins to form a coagulum. Post-translational modifications include N-glycosylation and proteolytic processing.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TGM4 Knockout HEK293 Cell Line | EDJ-KQ5198 | Human | 7047 | Details Get a Quote |
| TGM4 Knockout HeLa Cell Line | EDJ-KQ54650 | Human | 7047 | Details Get a Quote |
| TGM4 Knockout A-549 Cell Line | EDJ-KQ63130 | Human | 7047 | Details Get a Quote |
| TGM4 Knockout HCT 116 Cell Line | EDJ-KQ71604 | Human | 7047 | Details Get a Quote |
