TFDP1: Transcription Factor Dp-1 – A Key Regulator of Cell Cycle and E2F-Mediated Transcription
Comprehensive genomic, functional, and clinical overview of TFDP1, a dimerization partner of E2F transcription factors involved in cell proliferation and cancer.
Gene Information Card
| Symbol | TFDP1 |
|---|---|
| Full Name | Transcription factor Dp-1 |
| Gene Type | Protein coding |
| Chromosomal Location | 13q34 |
| NCBI Gene ID | 7027 ncbi.nlm.nih.gov/gene/7027 |
| Ensembl ID | ENSG00000139687 |
| UniProt ID | Q14186 |
| OMIM ID | 189902 |
| HGNC ID | 11749 |
| Aliases | DP1, Dp-1, E2F dimerization partner 1 |
Description
TFDP1 (Transcription Factor Dp-1) encodes a member of the DP family of transcription factors. The protein forms heterodimers with E2F family members, thereby regulating the expression of genes involved in cell cycle progression, DNA replication, and apoptosis. TFDP1 is essential for the transcriptional activity of E2F complexes and is a key component of the retinoblastoma (RB) tumor suppressor pathway. Alterations in TFDP1 expression or function have been implicated in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Retinoblastoma | TFDP1 dimerizes with E2F to regulate RB pathway; disruption contributes to tumorigenesis | OMIM #180200; PubMed studies |
| Lung cancer | Overexpression of TFDP1 promotes cell proliferation and invasion | COSMIC; PubMed |
| Breast cancer | TFDP1 amplification and overexpression linked to poor prognosis | COSMIC; PubMed |
| Colorectal cancer | TFDP1 upregulation associated with tumor progression | COSMIC; PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | High |
| Lymph node | 8.3 | Medium |
| Bone marrow | 7.1 | Medium |
| Brain | 4.2 | Low |
| Liver | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.2 | Cervical cancer cell line; high expression |
| A549 | 11.7 | Lung carcinoma; moderate-high |
| MCF7 | 9.4 | Breast cancer; moderate |
| HEK293 | 6.8 | Embryonic kidney; low-moderate |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.1% | Potential loss of start codon; likely loss-of-function |
| c.487C>T (p.Arg163Trp) | Missense | <0.1% | Unknown significance; reported in COSMIC |
| c.632_633insA (p.Gln211fs) | Frameshift | <0.1% | Loss-of-function; truncation |
| Amplification | Copy number gain | Variable | Gain-of-function; observed in multiple cancers |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations that truncate the protein, impairing dimerization with E2F and transcriptional activation.
Gain of Function (GOF)
Gene amplification or overexpression leading to increased E2F activity and enhanced cell cycle progression.
Dominant Negative (DN)
Missense mutations in the dimerization domain that disrupt E2F binding but retain partial function, potentially interfering with wild-type DP1.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Cell Cycle (KEGG hsa04110)
• E2F transcription factor network (Reactome R-HSA-8953897)
• Retinoblastoma (RB) pathway in cancer (Reactome R-HSA-5628897)
Protein Summary
TFDP1 encodes the 410-amino acid Transcription Factor Dp-1 protein. It contains a conserved DNA-binding/dimerization domain that mediates heterodimerization with E2F transcription factors. The DP1-E2F complex binds to E2F-responsive promoters to regulate genes essential for G1/S transition. Post-translational modifications, including phosphorylation, modulate its activity. TFDP1 is ubiquitously expressed with highest levels in testis and lymphoid tissues. Its dysregulation is linked to multiple cancer types.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TFDP1 Knockout HEK293 Cell Line | EDJ-KQ409 | Human | 7027 | Details Get a Quote |
| TFDP1 Knockout HCT 116 Cell Line | EDJ-KQ18663 | Human | 7027 | Details Get a Quote |
| TFDP1 Knockout HeLa Cell Line | EDJ-KQ18664 | Human | 7027 | Details Get a Quote |
| TFDP1 Knockout A-549 Cell Line | EDJ-KQ63124 | Human | 7027 | Details Get a Quote |
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