TEX36: Testis-Expressed Protein 36
A gene encoding a testis-specific protein of unknown function, with potential roles in spermatogenesis.
Gene Information Card
| Symbol | TEX36 |
|---|---|
| Full Name | testis expressed 36 |
| Gene Type | protein-coding |
| Chromosomal Location | 10q26.13 |
| NCBI Gene ID | 100131755 ncbi.nlm.nih.gov/gene/100131755 |
| Ensembl ID | ENSG00000204176 |
| UniProt ID | A6NKD9 |
| OMIM ID | - |
| HGNC ID | 34482 |
| Aliases | FLJ46361, MGC16384 |
Description
TEX36 (testis expressed 36) is a protein-coding gene located on chromosome 10q26.13. It encodes a protein of unknown function, but its expression is predominantly in testis, suggesting a potential role in spermatogenesis or male reproductive biology. The gene is conserved in mammals and has been identified in transcriptomic studies of testicular tissue.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Male infertility (spermatogenic failure) | Potential involvement in spermatogenesis; expression in testis suggests role in germ cell development. | No direct evidence; inferred from tissue expression (NCBI Gene, UniProt). |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Fallopian tube | 0.6 | Not detected |
| Ovary | 0.4 | Not detected |
| Prostate | 0.3 | Not detected |
| Other tissues | <0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 0.0 | Not expressed |
| K562 | 0.0 | Not expressed |
| HEK293 | 0.0 | Not expressed |
| Testis-derived cell lines | Not available | No data |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | - | - | - |
Mutation functional classification
Loss of Function (LOF)
No data available; no known loss-of-function mutations reported.
Gain of Function (GOF)
No data available; no known gain-of-function mutations reported.
Dominant Negative (DN)
No data available; no known dominant-negative mutations reported.
View complete mutation data：
Protein Summary
The TEX36 protein (UniProt A6NKD9) is a 244-amino acid polypeptide with no characterized domains or known function. It is predicted to be localized in the cytoplasm or nucleus based on sequence analysis. No structural or functional studies have been published.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TEX36 Knockout HEK293 Cell Line | EDC07821 | Human | 387718 | Details Get a Quote |
| TEX36 Knockout HeLa Cell Line | EDJ-KQ59986 | Human | 387718 | Details Get a Quote |
| TEX36 Knockout A-549 Cell Line | EDJ-KQ68448 | Human | 387718 | Details Get a Quote |
| TEX36 Knockout HCT 116 Cell Line | EDJ-KQ76825 | Human | 387718 | Details Get a Quote |
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