TEX19 (Testis Expressed 19) Gene
A germline-specific gene implicated in transposon silencing and potential roles in cancer and pluripotency
Gene Information Card
| Symbol | TEX19 |
|---|---|
| Full Name | Testis Expressed 19 |
| Gene Type | Protein coding |
| Chromosomal Location | 17q25.3 |
| NCBI Gene ID | 400629 ncbi.nlm.nih.gov/gene/400629 |
| Ensembl ID | ENSG00000182484 |
| UniProt ID | Q5VZB2 |
| OMIM ID | 616815 |
| HGNC ID | 30711 |
| Aliases | CT83, MGC26733 |
Description
TEX19 (Testis Expressed 19) is a protein-coding gene located on chromosome 17q25.3. It is predominantly expressed in the testis and plays a role in transposon silencing during germ cell development. TEX19 is also classified as a cancer/testis antigen (CT83) and is aberrantly expressed in various cancers, suggesting a potential role in tumorigenesis and pluripotency.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Aberrant expression of TEX19 in somatic tissues may contribute to tumorigenesis through reactivation of transposable elements and genomic instability. | COSMIC; literature (e.g., PMID: 25691456) |
| Male infertility | Disruption of TEX19 in mouse models leads to defective spermatogenesis and increased retrotransposon expression. | OMIM 616815; PMID: 23376485 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 28.5 | High |
| Thyroid | 0.2 | Not detected |
| Lung | 0.1 | Not detected |
| Brain | 0.0 | Not detected |
| Liver | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| NTERA-2 (embryonal carcinoma) | 15.2 | Cancer/testis antigen expression |
| Seminoma cell lines | 12.8 | Germ cell tumor model |
| HEK293 | 0.0 | No endogenous expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Potential loss of start codon; effect unknown |
| c.214C>T (p.Arg72Cys) | Missense | <0.01% | Rare variant; functional impact not characterized |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in human; mouse knockout shows spermatogenesis defects.
Gain of Function (GOF)
Not described.
Dominant Negative (DN)
Not described.
View complete mutation data：
Gene Ontology (GO)
| • molecular_function (GO:0003674) | • cellular_component (GO:0005575) |
| • biological_process (GO:0008150) |
Pathways
• No curated pathways available.
Protein Summary
TEX19 encodes a small protein of 164 amino acids (UniProt Q5VZB2) with no characterized domains. It is localized to the nucleus and cytoplasm. The protein is involved in repressing LINE-1 retrotransposons in germ cells, likely through interaction with the piRNA pathway or chromatin modifiers. Its expression is normally restricted to testis and placenta, but is reactivated in cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TEX19 Knockout HEK293 Cell Line | EDJ-KQ11575 | Human | 400629 | Details Get a Quote |
| TEX19 Knockout HCT 116 Cell Line | EDJ-KQ39911 | Human | 400629 | Details Get a Quote |
| TEX19 Knockout HeLa Cell Line | EDJ-KQ60268 | Human | 400629 | Details Get a Quote |
| TEX19 Knockout A-549 Cell Line | EDJ-KQ68730 | Human | 400629 | Details Get a Quote |
