TEX11 (Testis Expressed 11)
A key meiotic recombination factor essential for spermatogenesis and male fertility
Gene Information Card
| Symbol | TEX11 |
|---|---|
| Full Name | Testis Expressed 11 |
| Gene Type | Protein coding |
| Chromosomal Location | Xq13.1 |
| NCBI Gene ID | 56154 ncbi.nlm.nih.gov/gene/56154 |
| Ensembl ID | ENSG00000120438 |
| UniProt ID | Q8IYF3 |
| OMIM ID | 300311 |
| HGNC ID | 11733 |
| Aliases | SPGFX8, TEX11, MGC138290 |
Description
TEX11 (Testis Expressed 11) is a protein-coding gene located on the X chromosome. It encodes a meiotic recombination factor that is essential for homologous chromosome pairing, crossover formation, and completion of meiosis during spermatogenesis. Loss-of-function mutations in TEX11 are a known cause of non-obstructive azoospermia and male infertility.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Spermatogenic failure, X-linked, 8 (SPGFX8) | Loss-of-function mutations impair meiotic recombination, leading to meiotic arrest and azoospermia | OMIM #300311; multiple case-control studies |
| Non-obstructive azoospermia | Disruption of TEX11 prevents normal sperm production; hemizygous mutations in males cause complete absence of sperm | ClinVar; PubMed studies |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 32.5 | High |
| Fallopian tube | 0.8 | Low |
| Ovary | 0.6 | Low |
| Prostate | 0.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Testis (spermatocytes) | High | Enriched in meiotic cells |
| HEK293 | Low | Minimal expression |
| K562 | Not detected | No expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.495_496delAG (p.Glu166Aspfs*2) | Frameshift deletion | Rare | Loss of function; meiotic arrest |
| c.1003C>T (p.Arg335*) | Nonsense | Rare | Premature stop; loss of function |
| c.1385G>A (p.Trp462*) | Nonsense | Rare | Loss of function; associated with azoospermia |
Mutation functional classification
Loss of Function (LOF)
Most reported TEX11 mutations are loss-of-function (nonsense, frameshift, splice-site) leading to truncated or absent protein, causing meiotic arrest and azoospermia.
Gain of Function (GOF)
No gain-of-function mutations have been reported for TEX11.
Dominant Negative (DN)
No dominant-negative mutations have been described; TEX11 is X-linked and hemizygous in males.
View complete mutation data：
Gene Ontology (GO)
| • reciprocal meiotic recombination (GO:0007131) | • condensed nuclear chromosome (GO:0000794) |
| • nucleus (GO:0005634) | • synapsis (GO:0007129) |
| • meiotic DNA double-strand break processing (GO:0007135) |
Pathways
• Meiotic recombination (Reactome: R-HSA-912446)
• Homologous recombination (KEGG: hsa03440)
Protein Summary
The TEX11 protein is a 1,002-amino acid meiotic factor localized to the nucleus. It contains a conserved domain of unknown function (DUF) and is involved in crossover formation and chromosome synapsis during prophase I of meiosis. It interacts with other meiotic proteins such as SPO11 and DMC1 to facilitate homologous recombination. Loss of TEX11 leads to meiotic arrest at the zygotene/pachytene stage, resulting in azoospermia.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TEX11 Knockout HEK293 Cell Line | EDJ-KQ15690 | Human | 56159 | Details Get a Quote |
| TEX11 Knockout HeLa Cell Line | EDJ-KQ56714 | Human | 56159 | Details Get a Quote |
| TEX11 Knockout A-549 Cell Line | EDJ-KQ65220 | Human | 56159 | Details Get a Quote |
| TEX11 Knockout HCT 116 Cell Line | EDJ-KQ73657 | Human | 56159 | Details Get a Quote |
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