TESC (Tescalcin) Gene
Calcium-binding protein gene involved in cell differentiation and cancer
Gene Information Card
| Symbol | TESC |
|---|---|
| Full Name | Tescalcin |
| Gene Type | Protein-coding |
| Chromosomal Location | 12q24.22 |
| NCBI Gene ID | 54997 ncbi.nlm.nih.gov/gene/54997 |
| Ensembl ID | ENSG00000135446 |
| UniProt ID | Q96BS2 |
| OMIM ID | 611585 |
| HGNC ID | 26071 |
| Aliases | CHP3, TSC, FLJ20607 |
Description
TESC (tescalcin) encodes a calcium-binding protein belonging to the calcineurin B-like family. It is involved in cell differentiation, particularly in hematopoietic and neuronal cells, and modulates calcineurin-NFAT signaling. TESC is also implicated in cancer progression and has been studied in the context of gastric, colorectal, and other malignancies.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Gastric Cancer | Overexpression of TESC promotes cell proliferation and invasion via activation of NF-κB and Wnt/β-catenin pathways | PMID: 23434587 |
| Colorectal Cancer | TESC upregulation correlates with poor prognosis and enhances tumor growth through calcineurin/NFAT signaling | PMID: 25636847 |
| Hepatocellular Carcinoma | TESC expression is elevated and associated with metastasis and EMT via PI3K/Akt pathway | PMID: 27158355 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 4.2 | Low |
| Heart | 1.8 | Not detected |
| Liver | 0.5 | Not detected |
| Kidney | 3.1 | Low |
| Testis | 12.5 | Medium |
| Stomach | 6.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 8.3 | Moderate expression |
| K562 | 15.1 | High expression |
| HeLa | 5.6 | Low expression |
| MCF7 | 2.4 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.236C>T (p.Pro79Leu) | Missense | <0.1% | Unknown functional impact |
| c.412G>A (p.Glu138Lys) | Missense | <0.1% | Unknown functional impact |
| c.523_524insA | Frameshift | <0.1% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.523_524insA) are predicted to cause loss of function due to premature truncation.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in TESC.
Dominant Negative (DN)
No evidence of dominant-negative effects for TESC mutations.
View complete mutation data：
Gene Ontology (GO)
| • calcium ion binding (GO:0005509) | • cytoplasm (GO:0005737) |
| • nucleus (GO:0005634) | • protein binding (GO:0005515) |
| • metal ion binding (GO:0046872) |
Pathways
• Calcineurin-NFAT signaling pathway
• Wnt/β-catenin signaling pathway
• PI3K/Akt signaling pathway
Protein Summary
Tescalcin is a 214-amino acid calcium-binding protein with two EF-hand domains. It localizes to the cytoplasm and nucleus, and modulates calcineurin activity, thereby influencing NFAT-dependent transcription. Tescalcin is involved in cell differentiation, particularly in hematopoietic and neuronal lineages, and its dysregulation contributes to cancer cell proliferation, migration, and invasion.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TESC Knockout HEK293 Cell Line | EDJ-KQ12034 | Human | 54997 | Details Get a Quote |
| TESC Knockout HeLa Cell Line | EDJ-KQ39394 | Human | 54997 | Details Get a Quote |
| TESC Knockout A-549 Cell Line | EDJ-KQ40651 | Human | 54997 | Details Get a Quote |
| TESC Knockout HCT 116 Cell Line | EDJ-KQ40652 | Human | 54997 | Details Get a Quote |
